Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22987342 | 0.82 | RECQL (0.53) | RECQLALDH1A1LMNAGAATSHR | |
| SCHEMBL25122213 | 0.82 | RECQL (0.53) | RECQLALDH1A1LMNAGAATSHR | |
| SCHEMBL22987392 | 0.80 | ALDH1A1 (0.38) | RECQLALDH1A1LMNATSHRCAPN1 | |
| SCHEMBL17571001 | 0.77 | RECQL (0.65) | RECQLALDH1A1LMNAGAATSHR | |
| SCHEMBL19471807 | 0.77 | RECQL (0.69) | RECQLALDH1A1LMNAGAATSHR | |
| SCHEMBL1121020 | 0.73 | CA12 (0.40) | RECQLALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL25051421 | 0.73 | RECQL (0.42) | RECQLALDH1A1GAAPSMB5CAPN1 | |
| SCHEMBL20436735 | 0.71 | RECQL (0.41) | RECQLGAAPSMB5SMN1; SMN2CAPN1 | |
| SCHEMBL21418111 | 0.70 | PSMB5 (0.51) | RECQLGAAPSMB5SMN1; SMN2CAPN1 | |
| SCHEMBL21446918 | 0.70 | MEN1 (0.44) | ALDH1A1GAATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189056-B1 | CYTOTOXIC BENZODIAZEPINE DERIVATIVES | IMMUNOGEN INC (US) | 2020-06-10 | — | — | EP | disclosed |