Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.54 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.54 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.54 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20631173 | 0.82 | POLB (0.70) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20631014 | 0.82 | POLB (0.57) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL22065498 | 0.81 | ALDH1A1 (0.48) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20631693 | 0.80 | POLB (0.55) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20631694 | 0.80 | ALDH1A1 (0.59) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20630576 | 0.79 | ALDH1A1 (0.58) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20631234 | 0.79 | POLB (0.64) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20631219 | 0.79 | POLB (0.64) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL20631672 | 0.78 | GAA (0.65) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 | |
| SCHEMBL22028715 | 0.78 | GAA (0.65) | ALDH1A1DUSP3PTPN5PTPN11SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200181101-A1 | BENZAMIDE INHIBITORS OF BACTERIAL LIPOPROTEIN SIGNAL PEPTIDASE | SCRIPPS RESEARCH INST (US) | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200181101-A1 | BENZAMIDE INHIBITORS OF BACTERIAL LIPOPROTEIN SIGNAL PEPTIDASE | LPL, LIPE, LYPLA2 | ALDH1A1 3104/4885DUSP3 2217/4885PTPN5 2541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.