SCHEMBL22068545

SCHEMBL22068545

COc1ccc(C(C)(C)CC(C)(C)C)cc1C1C(=O)Oc2ccc(C(C)(C)CC(C)(C)C)cc21

nearest known ligand 0.43

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.40
ALDH1A1 P00352 6/20 0.37
HPGD P15428 1/20 0.37
GAA P10253 1/20 0.36
MDH1 P40925 1/20 0.35
MDH2 P40926 1/20 0.35
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
TDP1 Q9NUW8 2/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
CYP3A4 P08684 1/20 0.33
SHBG P04278 1/20 0.32
PDE4B Q07343 1/20 0.31
RECQL P46063 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23071660 0.94 MAPT (0.37) MAPTALDH1A1HPGDGAAMDH1
SCHEMBL23071652 0.88 GAA (0.34) MAPTALDH1A1HPGDGAASMN1; SMN2
SCHEMBL18590074 0.88 GAA (0.34) MAPTALDH1A1HPGDGAASMN1; SMN2
SCHEMBL22202050 0.87 GAA (0.34) MAPTALDH1A1HPGDGAASMN1; SMN2
SCHEMBL466198 0.87 GAA (0.34) MAPTALDH1A1HPGDGAAMDH1
SCHEMBL22068557 0.87 GAA (0.34) MAPTALDH1A1HPGDGAASMN1; SMN2
SCHEMBL22068548 0.86 MAPT (0.52) MAPTALDH1A1HPGDGAAMEN1
SCHEMBL23071657 0.84 MAPT (0.36) MAPTALDH1A1HPGDGAA
SCHEMBL17172384 0.84 GAA (0.41) MAPTALDH1A1HPGDGAACYP3A4
SCHEMBL14556835 0.82 CYP3A4 (0.41) MAPTALDH1A1HPGDGAAMDH1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220145053-A1 Stabilized Polyolefin Compositions Comprising Benzofuranones and Hindered Phenolic Antioxidants BASF SE (DE) 2022-05-12 US disclosed
US-10941286-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered amine light stabilizers BASF SE (DE) 2021-03-09 US disclosed
US-10934423-B2 Stabilized polyolefin compositions comprising benzofuranones and organophosphorus stabilizers BASF SE (DE) 2021-03-02 US disclosed
US-10913841-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered phenolic antioxidants BASF SE (DE) 2021-02-09 US disclosed
US-20200216638-A1 Stabilized Polyolefin Compositions Comprising Benzofuranones and Hindered Amine Light Stabilizers BASF SCHWEIZ AG (CH) 2020-07-09 US disclosed
US-20200181364-A1 Stabilized Polyolefin Compositions Comprising Benzofuranones and Acid Scavengers BASF SCHWEIZ AG (CH) 2020-06-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10941286-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered amine light stabilizers PUF60, PARG, PARN MAPT 140/4885ALDH1A1 1248/4885HPGD 3621/4885
US-10913841-B2 Stabilized polyolefin compositions comprising benzofuranones and hindered phenolic antioxidants PUF60, GPX4, BPTF MAPT 861/4885ALDH1A1 1045/4885HPGD 1499/4885
US-10934423-B2 Stabilized polyolefin compositions comprising benzofuranones and organophosphorus stabilizers PUF60, MORF4L1, BRPF1 MAPT 1239/4885ALDH1A1 3588/4885HPGD 3787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.