Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205963 | 0.85 | LMNA (0.43) | ALDH1A1LMNAPTBP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL22942130 | 0.72 | KMT2A (0.41) | ALDH1A1LMNAPTBP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2203494 | 0.72 | TSHR (0.46) | ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL8089043 | 0.70 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2L3MBTL1KDM4E | |
| SCHEMBL2206981 | 0.69 | LMNA (0.61) | ALDH1A1LMNAPTBP1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14993998 | 0.69 | PDGFRB (0.62) | ALDH1A1LMNASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL2955974 | 0.69 | ALDH1A1 (0.53) | ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL29738113 | 0.69 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL2944676 | 0.69 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL9024763 | 0.68 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188292-B1 | 2- [ (2-{PHENYLAMINO}-1H-PYRROLO [2, 3-D]PYRIMIDIN-4-YL) AMINO]BENZAMIDE DERIVATIVES AS IGF-1R INHIBITORS FOR THE TREATMENT OF CANCER | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-29 | — | — | EP | disclosed |
| US-7981903-B2 | 2-[2-{phenylamino}-1H-pyrrolo[2,3-D]pyrimidin-4-yl)amino] benzamide derivatives as IGF-1R inhibitors for the treatment of cancer | GLAXOSMITHKLINE LLC (US) | 2011-07-19 | — | — | US | disclosed |
| US-20100204196-A1 | 2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer | GLAXOSMITHKLINE LLC | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204196-A1 | 2-[2--1H-Pyrrolo[2,3-D]Pyrimidin-4-YL)Amino] Benzamide Derivatives As IGF-1R Inhibitors For The Treatment Of Cancer | IGF1R, IGFBP2, IGFBP1 | ALDH1A1 378/4885LMNA 4161/4885PTBP1 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.