Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Toluene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR known ✓ | P00533 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyridine SCHEMBL3261023 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL20958 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL7656088 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL2126952 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL6427981 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL31483849 | 0.96 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL5968326 | 0.95 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Toluene SCHEMBL29249545 | 0.95 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL28981792 | 0.95 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 | |
| Pyridine SCHEMBL28538739 | 0.95 | ALDH1A1 (0.57) | ALDH1A1SMN1; SMN2KDM4EMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12247089-B2 | Photo-coupled synergistically crosslinked hydrogel material and its composition, preparation method, use, product, and preparation kit | Zhongshan Guanghe Medical Technology Co., Ltd. (CN) | 2025-03-11 | — | — | US | disclosed |
| US-11117879-B2 | Photo-crosslinked hydrogel material and preparation, composition, and application thereof photo-crosslinked hydrogel | Zhongshan Guanghe Medical Technology Co., Ltd. (CN) | 2021-09-14 | — | — | US | disclosed |
| US-20200262802-A1 | PHOTO-CROSSLINKED HYDROGEL MATERIAL AND PREPARATION, COMPOSITION, AND APPLICATION THEREOF PHOTO-CROSSLINKED HYDROGEL | Zhongshan Guanghe Medical Technology Co., Ltd. (CN) | 2020-08-20 | — | — | US | disclosed |
| US-20200262939-A1 | PHOTO-COUPLED SYNERGISTICALLY CROSSLINKED HYDROGEL MATERIAL AND ITS COMPOSITION, PREPARATION METHOD, USE, PRODUCT, AND PREPARATION KIT | Zhongshan Guanghe Medical Technology Co., Ltd. (CN) | 2020-08-20 | — | — | US | disclosed |
| EP-3666761-A1 | PREPARATION, RAW MATERIALS, PRODUCT, AND APPLICATION OF PHOTOCROSSLINKED HYDROGEL MATERIAL | Zhongshan Guanghe Medical Technology Co., Ltd. (CN) | 2020-06-17 | — | — | EP | disclosed |
| CN-107674013-A | Polycyclic compound, its preparation method, pharmaceutical composition and application | 上海迪诺医药科技有限公司 | 2018-02-09 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200262802-A1 | PHOTO-CROSSLINKED HYDROGEL MATERIAL AND PREPARATION, COMPOSITION, AND APPLICATION THEREOF PHOTO-CROSSLINKED HYDROGEL | JAK3, ILK, JAK1 | EGFR 2655/4885ALDH1A1 964/4885SMN1; SMN2 4120/4885 |
| US-12247089-B2 | Photo-coupled synergistically crosslinked hydrogel material and its composition, preparation method, use, product, and preparation kit | PKN3, JAK3, KIT | EGFR 3004/4885ALDH1A1 92/4885SMN1; SMN2 4066/4885 |
| US-20200262939-A1 | PHOTO-COUPLED SYNERGISTICALLY CROSSLINKED HYDROGEL MATERIAL AND ITS COMPOSITION, PREPARATION METHOD, USE, PRODUCT, AND PREPARATION KIT | PKN3, JAK3, KIT | EGFR 3004/4885ALDH1A1 92/4885SMN1; SMN2 4066/4885 |
| US-11117879-B2 | Photo-crosslinked hydrogel material and preparation, composition, and application thereof photo-crosslinked hydrogel | JAK3, ILK, JAK1 | EGFR 2655/4885ALDH1A1 964/4885SMN1; SMN2 4120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.