Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 15/20 | 1.00 |
| ▸ | ACVR1B | P36896 | 15/20 | 0.79 |
| ▸ | BMPR1A | P36894 | 14/20 | 0.79 |
| ▸ | ACVRL1 | P37023 | 14/20 | 0.79 |
| ▸ | BMPR1B | O00238 | 12/20 | 0.79 |
| ▸ | BMP4 | P12644 | 4/20 | 0.79 |
| ▸ | KDR | P35968 | 4/20 | 0.79 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.79 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.79 |
| ▸ | BMPR2 | Q13873 | 4/20 | 0.79 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.79 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.79 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.79 |
| ▸ | ACVR2B | Q13705 | 1/20 | 0.79 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL22027719 | 0.99 | ACVR1 (0.98) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| SCHEMBL22074613 | 0.90 | ACVR1 (0.81) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| SCHEMBL29353046 | 0.89 | ACVR1 (1.00) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| SCHEMBL456393 | 0.89 | ACVR1 (1.00) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| SCHEMBL22074566 | 0.88 | ACVR1 (0.78) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| SCHEMBL16134950 | 0.88 | ACVR1 (1.00) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| Hydrochloric Acid SCHEMBL29634729 | 0.88 | ACVR1 (0.98) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| Hydrochloric Acid SCHEMBL2059683 | 0.88 | ACVR1 (0.98) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| Hydrochloric Acid SCHEMBL29373122 | 0.88 | ACVR1 (0.98) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B | |
| Hydrochloric Acid SCHEMBL22462135 | 0.88 | ACVR1 (0.98) | ACVR1ACVR1BBMPR1AACVRL1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230398118-A1 | METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE | KEROS THERAPEUTICS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-20230398118-A1 | METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE | KEROS THERAPEUTICS, INC. | 2023-12-14 | — | — | US | disclosed |
| US-20230372390-A1 | METHODS OF TREATING LYMPHOPENIA | KEROS THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
| US-20230372390-A1 | METHODS OF TREATING LYMPHOPENIA | KEROS THERAPEUTICS, INC. | 2023-11-23 | — | — | US | disclosed |
| US-11654147-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-11654147-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2023-05-23 | — | — | US | disclosed |
| US-20230000869-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2023-01-05 | — | — | US | disclosed |
| US-20220401445-A1 | METHODS OF USING ALK2 INHIBITORS | KEROS THERAPEUTICS, INC. | 2022-12-22 | — | — | US | disclosed |
| WO-2022098812-A1 | METHODS OF TREATING IRON OVERLOAD | KEROS THERAPEUTICS, INC. (US) | 2022-05-12 | — | — | WO | disclosed |
| US-11026947-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2021-06-08 | — | — | US | disclosed |
| US-20200179389-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-06-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220401445-A1 | METHODS OF USING ALK2 INHIBITORS | ALK, ACVR2A, ACVR1 | ACVR1 3/4885ACVR1B 9/4885BMPR1A 32/4885 |
| US-20200179389-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | BMPR2, BMP1, BMP2K | ACVR1 6/4885ACVR1B 15/4885BMPR1A 5/4885 |
| US-20230000869-A1 | NOVEL ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING | BMPR2, BMP1, BMP2K | ACVR1 6/4885ACVR1B 15/4885BMPR1A 5/4885 |
| US-20230398118-A1 | METHODS OF TREATING CARDIOVASCULAR-RELATED DISEASE | BMPR2, BMP1, BMP2 | ACVR1 13/4885ACVR1B 20/4885BMPR1A 8/4885 |
| US-11654147-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | BMPR2, BMP1, BMP2K | ACVR1 6/4885ACVR1B 15/4885BMPR1A 5/4885 |
| US-11026947-B2 | ALK2 inhibitors and methods for inhibiting BMP signaling | BMPR2, BMP1, BMP2K | ACVR1 6/4885ACVR1B 15/4885BMPR1A 5/4885 |
| US-20230372390-A1 | METHODS OF TREATING LYMPHOPENIA | HAMP, BMPR2, BMP2 | ACVR1 16/4885ACVR1B 15/4885BMPR1A 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.