Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 2/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 7/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 2/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | DDX3X | O00571 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19127037 | 0.77 | LDHA (0.44) | LDHANOTUMMIFALDH1A1P2RX7 | |
| SCHEMBL19144674 | 0.74 | ATM (0.47) | LDHANOTUMMIFRXRAGRIN1 | |
| SCHEMBL19126510 | 0.72 | PSMD10 (0.55) | NOTUMMIFP2RX7 | |
| SCHEMBL14212120 | 0.71 | LDHA (0.70) | LDHANOTUMMIFRXRAGRIN1 | |
| SCHEMBL19933835 | 0.69 | RXRA (0.57) | NOTUMRXRAGRIN1GRIN2B | |
| SCHEMBL22629818 | 0.67 | MAPT (0.67) | NOTUMRXRAGRIN1GRIN2BALDH1A1 | |
| SCHEMBL19127484 | 0.67 | MIF (0.55) | NOTUMMIFRXRAGRIN1GRIN2B | |
| SCHEMBL20676213 | 0.67 | POLB (0.45) | NOTUMALDH1A1 | |
| SCHEMBL19145227 | 0.66 | NOTUM (0.38) | NOTUMMIFALDH1A1P2RX7 | |
| SCHEMBL19144500 | 0.66 | MAOA (0.58) | NOTUMMIFALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | LDHA 2053/4885NOTUM 4734/4885MIF 4801/4885 |
| US-11186562-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | LDHA 2053/4885NOTUM 4734/4885MIF 4801/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.