Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MIF | P14174 | 2/20 | 0.43 |
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RXRA | P19793 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19127037 | 0.92 | LDHA (0.44) | ATMMIFLDHAP2RX7NOTUM | |
| SCHEMBL19126538 | 0.79 | GPR119 (0.44) | ATMALDH1A1GLA | |
| SCHEMBL22075891 | 0.74 | LDHA (0.47) | MIFLDHAP2RX7NOTUMALDH1A1 | |
| SCHEMBL19145598 | 0.73 | ATM (0.38) | ATMMIFALDH1A1 | |
| SCHEMBL19126510 | 0.72 | PSMD10 (0.55) | MIFP2RX7NOTUM | |
| SCHEMBL9200019 | 0.71 | MTNR1A (0.60) | ATMALDH1A1 | |
| SCHEMBL5449877 | 0.71 | ATM (0.57) | ATMALDH1A1 | |
| SCHEMBL19674140 | 0.71 | ATM (0.57) | ATMALDH1A1 | |
| SCHEMBL21810428 | 0.70 | NTSR1 (0.57) | ATM | |
| SCHEMBL14876504 | 0.70 | NTSR1 (0.57) | ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2023-01-26 | — | — | US | disclosed |
| US-11186562-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-30 | — | — | US | disclosed |
| US-11174241-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2021-11-16 | — | — | US | disclosed |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2020-06-18 | — | — | US | disclosed |
| US-10669251-B2 | Quinolin-2-one derivatives | MERCK PATENT GMBH (DE) | 2020-06-02 | — | — | US | disclosed |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2019-01-24 | — | — | US | disclosed |
| WO-2017121444-A1 | QUINOLIN-2-ONE DERIVATIVES | MERCK PATENT GMBH (DE) | 2017-07-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11174241-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
| US-20190023685-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
| US-20200190054-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
| US-20230028687-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
| US-20200190055-A1 | QUINOLIN-2-ONE DERIVATIVES | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
| US-10669251-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
| US-11186562-B2 | Quinolin-2-one derivatives | KIT, CDK2, CDK1 | ATM 419/4885MIF 4801/4885LDHA 2053/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.