Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA3 | P07451 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2205399 | 0.81 | KDM1A (0.37) | RECQLTSHRPOLBCA12CA2 | |
| SCHEMBL7806682 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL2210791 | 0.74 | HTR4 (0.53) | KDM4EALDH1A1RECQLPOLBCA12 | |
| SCHEMBL3336282 | 0.73 | TSHR (0.47) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL3336866 | 0.72 | BAZ2B (0.49) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL3336295 | 0.72 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL3337719 | 0.72 | KDM4E (0.49) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL21295035 | 0.71 | TSHR (0.51) | KDM4EALDH1A1HSD17B10RECQLTSHR | |
| SCHEMBL3336291 | 0.70 | TSHR (0.45) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL17554436 | 0.70 | KDM1A (0.52) | KDM4EALDH1A1HPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7982040-B2 | Thienopyridinone compounds and methods of treatment | NANOTHERAPEUTICS, INC. (US) | 2011-07-19 | — | — | US | disclosed |
| US-7576211-B2 | Synthesis of thienopyridinone compounds and related intermediates | EPIX DELAWARE, INC. (US) | 2009-08-18 | — | — | US | disclosed |
| US-20090163537-A1 | Thienopyridinone Compounds and Methods of Treatment | NANOSHIFT, LLC | 2009-06-25 | — | — | US | disclosed |
| US-7488736-B2 | Thienopyridinone compounds and methods of treatment | EPIX DELAWARE, INC. (US) | 2009-02-10 | — | — | US | disclosed |
| EP-1746994-A4 | THIENOPYRIDINONE COMPOUNDS AND METHODS OF TREATMENT | EPIX DELAWARE INC (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1746994-A2 | THIENOPYRIDINONE COMPOUNDS AND METHODS OF TREATMENT | Epix Delaware, Inc. (US) | 2007-01-31 | — | — | EP | disclosed |
| US-20060084805-A1 | Synthesis of thienopyridinone compounds and related intermediates | NANOSHIFT, LLC | 2006-04-20 | — | — | US | disclosed |
| WO-2005121151-A2 | THIENOPYRIDINONE COMPOUNDS AND METHODS OF TREATMENT | EPIX DELAWARE, INC. (US) | 2005-12-22 | — | — | WO | disclosed |
| US-20050256153-A1 | Thienopyridinone compounds and methods of treatment | NANOSHIFT, LLC | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163537-A1 | Thienopyridinone Compounds and Methods of Treatment | HTR5A, GIPR, TBXA2R | KDM4E 3279/4885ALDH1A1 762/4885HPGD 268/4885 |
| US-20060084805-A1 | Synthesis of thienopyridinone compounds and related intermediates | HTR5A, GIPR, HTR1A | KDM4E 3570/4885ALDH1A1 733/4885HPGD 211/4885 |
| US-20050256153-A1 | Thienopyridinone compounds and methods of treatment | HTR5A, GIPR, TBXA2R | KDM4E 3279/4885ALDH1A1 762/4885HPGD 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.