Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | METTL3 | Q86U44 | 7/20 | 0.35 |
| ▸ | SCN2B | O60939 | 1/20 | 0.34 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | PDE11A | Q9HCR9 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22032012 | 0.84 | SRC (0.39) | SRCADKMETTL3CA12CA1 | |
| SCHEMBL24072905 | 0.78 | SRC (0.50) | SRCADKPDE11ACA12CA1 | |
| SCHEMBL24072610 | 0.76 | SRC (0.50) | SRCADKPDE11ACA12CA1 | |
| SCHEMBL19264154 | 0.75 | SRC (0.67) | SRCADKPDE11AEGFRCDK1 | |
| SCHEMBL22086092 | 0.72 | SRC (0.69) | SRCPDE11ACA12CA1CA2 | |
| SCHEMBL20351787 | 0.70 | LMNA (0.50) | SRCADKRXFP1TP53MAPT | |
| SCHEMBL20911835 | 0.70 | SRC (0.43) | SRCADKMETTL3CA12CA1 | |
| SCHEMBL30372943 | 0.70 | SRC (0.43) | SRCADKMETTL3CA12CA1 | |
| SCHEMBL30372478 | 0.68 | SRC (0.47) | SRCPDE11ACA12CA1CA2 | |
| SCHEMBL16683457 | 0.67 | ELOVL1 (0.37) | SCN2BSCN1BSCN9ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020115481-A1 | MAP4K4 INHIBITORS | IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE (GB) | 2020-06-11 | — | — | WO | disclosed |