Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.37 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.35 |
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | UTRN | P46939 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30017239 | 1.00 | ROCK1 (0.37) | ROCK1ASIC3HCRTR1HCRTR2BACE1 | |
| SCHEMBL469901 | 0.82 | GABRP (0.39) | ASIC3LOXLOXL2NOS3NOS1 | |
| SCHEMBL16642357 | 0.80 | UHRF1 (0.45) | HCRTR1HCRTR2BACE1LOXLOXL2 | |
| SCHEMBL30992022 | 0.80 | UHRF1 (0.45) | HCRTR1HCRTR2BACE1LOXLOXL2 | |
| SCHEMBL5323718 | 0.78 | LOX (0.38) | ASIC3BACE1LOXLOXL2NOS3 | |
| SCHEMBL29072675 | 0.78 | HCRTR1 (0.34) | ROCK1HCRTR1HCRTR2BACE1LOX | |
| SCHEMBL30117106 | 0.78 | HCRTR1 (0.34) | ROCK1HCRTR1HCRTR2BACE1LOX | |
| SCHEMBL27958617 | 0.78 | GRM4 (0.39) | ROCK1HCRTR1HCRTR2UTRNKDM4E | |
| SCHEMBL20606987 | 0.77 | ACACB (0.38) | ASIC3LOXLOXL2PDE4DACACB | |
| SCHEMBL19773753 | 0.77 | NR1H2 (0.35) | HCRTR1HCRTR2UTRNNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503467-B2 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | IDEAYA BIOSCIENCES, INC. (US) | 2025-12-23 | — | — | US | disclosed |
| US-20250313549-A1 | HERBICIDAL DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2025-10-09 | — | — | US | disclosed |
| US-12384773-B2 | Thiazole compounds and methods of use thereof | ARCUS BIOSCIENCES, INC. (US) | 2025-08-12 | — | — | US | disclosed |
| US-20250145606-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-05-08 | — | — | US | disclosed |
| WO-2025096979-A1 | THIAZOLE COMPOUNDS AS KIT INHIBITORS AND METHODS OF USE THEREOF | ARCUS BIOSCIENCES, INC. (US) | 2025-05-08 | — | — | WO | disclosed |
| EP-4433467-A1 | HERBICIDAL DERIVATIVES | Syngenta Crop Protection AG (CH) | 2024-09-25 | — | — | EP | disclosed |
| CN-118265705-A | Herbicidal derivatives | 先正达农作物保护股份公司 | 2024-06-28 | — | — | CN | disclosed |
| WO-2023088921-A1 | HERBICIDAL DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2023-05-25 | — | — | WO | disclosed |
| WO-2023088921-A1 | HERBICIDAL DERIVATIVES | SYNGENTA CROP PROTECTION AG (CH) | 2023-05-25 | — | — | WO | disclosed |
| US-20220411406-A1 | LPA RECEPTOR ANTAGONISTS AND USES THEREOF | GILEAD SCIENCES, INC. | 2022-12-29 | — | — | US | disclosed |
| CN-113264945-B | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2022-11-22 | — | — | CN | disclosed |
| US-20220106276-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2022-04-07 | — | — | US | disclosed |
| EP-3894396-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | Ideaya Biosciences, Inc. (US) | 2021-10-20 | — | — | EP | disclosed |
| US-11130759-B1 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | IDEAYA BIOSCIENCE, INC. (US) | 2021-09-28 | — | — | US | disclosed |
| CN-113264945-A | Spiro derivative, preparation method and medical application thereof | 江苏恒瑞医药股份有限公司 | 2021-08-17 | — | — | CN | disclosed |
| US-11084798-B1 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | IDEAYA BIOSCIENCES, INC. (US) | 2021-08-10 | — | — | US | disclosed |
| CN-113166078-A | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | 伊迪亚生物科学有限公司 | 2021-07-23 | — | — | CN | disclosed |
| US-11046691-B1 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | IDEAYA BIOSCIENCES, INC. (US) | 2021-06-29 | — | — | US | disclosed |
| WO-2020123395-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-06-18 | — | — | WO | disclosed |
| CN-103763923-A | 3-alkoxy-4-amino-6- (substituted) picolinates, 3-thioalkyl-4-amino-6- (substituted) picolinates, and 3-amino-4-amino-6- (substituted) picolinates and their use as herbicides | DOW AGRO SCIENCES LLC | 2014-04-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11046691-B1 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | MAT2B, MAT2A, MAT1A | ROCK1 2870/4885ASIC3 4740/4885HCRTR1 4531/4885 |
| US-12384773-B2 | Thiazole compounds and methods of use thereof | TPMT, CYP11B2, ABAT | ROCK1 3622/4885ASIC3 3409/4885HCRTR1 2543/4885 |
| US-20220411406-A1 | LPA RECEPTOR ANTAGONISTS AND USES THEREOF | LPAR1, LPAR2, LPAR4 | ROCK1 311/4885ASIC3 2855/4885HCRTR1 659/4885 |
| US-11130759-B1 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | MAT2B, MAT2A, MAT1A | ROCK1 2870/4885ASIC3 4740/4885HCRTR1 4531/4885 |
| US-20250145606-A1 | THIAZOLE COMPOUNDS AND METHODS OF USE THEREOF | TPMT, CYP11B2, ABAT | ROCK1 3622/4885ASIC3 3409/4885HCRTR1 2543/4885 |
| US-11084798-B1 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | MAT2B, MAT2A, MAT1A | ROCK1 2870/4885ASIC3 4740/4885HCRTR1 4531/4885 |
| US-20250313549-A1 | HERBICIDAL DERIVATIVES | DDT, CYP1B1, CYP1A1 | ROCK1 3360/4885ASIC3 2557/4885HCRTR1 577/4885 |
| US-20220106276-A1 | 2-OXOQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | MAT2B, MAT2A, MAT1A | ROCK1 2870/4885ASIC3 4740/4885HCRTR1 4531/4885 |
| US-12503467-B2 | 2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors | MAT2B, MAT2A, MAT1A | ROCK1 2870/4885ASIC3 4740/4885HCRTR1 4531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.