Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.32 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8489704 | 0.75 | CYP2A6 (0.39) | LMNARAB9ASMN1; SMN2NPC1PKM | |
| SCHEMBL2403041 | 0.70 | CA1 (0.42) | LMNANFKB1ALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL12733667 | 0.67 | SMN1; SMN2 (0.50) | LMNARAB9ASMN1; SMN2NPC1PKM | |
| SCHEMBL509508 | 0.65 | CYP3A4 (0.43) | LMNAALDH1A1KDM4EPOLBMAPT | |
| SCHEMBL19820327 | 0.65 | SLC6A4 (0.40) | ALDH1A1HPGDCYP2A6ELANECTRB1 | |
| SCHEMBL17557169 | 0.64 | LMNA (0.46) | LMNARAB9ASMN1; SMN2NPC1PKM | |
| SCHEMBL30223245 | 0.64 | HTR3A (0.45) | RAB9ASMN1; SMN2NPC1PKMNFKB1 | |
| SCHEMBL22025567 | 0.63 | CYP1A2 (0.52) | LMNAALDH1A1CYP2A6CYP1A2 | |
| SCHEMBL21600931 | 0.63 | ACHE (0.43) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL7923598 | 0.62 | CYP2A6 (0.44) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3893645-A1 | SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME | Arbutus Biopharma Corporation (CA) | 2021-10-20 | — | — | EP | disclosed |
| WO-2020123674-A1 | SUBSTITUTED ARYLMETHYLUREAS AND HETEROARYLMETHYLUREAS, ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-06-18 | — | — | WO | disclosed |