Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 9/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22100758 | 0.84 | NPC1 (0.56) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL22100829 | 0.79 | TRPM8 (0.60) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10271044 | 0.75 | TRPM8 (1.00) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14822016 | 0.71 | TRPM8 (0.69) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL10914231 | 0.70 | NPC1 (0.66) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL15276661 | 0.68 | TRPM8 (0.64) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14821807 | 0.68 | TRPM8 (0.61) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14822030 | 0.68 | ALDH1A1 (0.52) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL22100766 | 0.67 | TRPM8 (0.55) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14822012 | 0.67 | TRPM8 (0.60) | TRPM8NPC1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |