Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 9/20 | 1.00 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10271037 | 1.00 | TRPM8 (1.00) | TRPM8NFE2L2ALDH1A1MAPTHPGD | |
| SCHEMBL10271034 | 0.85 | TRPM8 (1.00) | TRPM8ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL10271038 | 0.80 | TRPM8 (1.00) | TRPM8NFE2L2MAPTKMT2ACYP1A1 | |
| SCHEMBL10270947 | 0.77 | TRPM8 (1.00) | TRPM8ALDH1A1KDM4EPOLB | |
| SCHEMBL1699151 | 0.76 | TRPM8 (1.00) | TRPM8ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL1699149 | 0.76 | TRPM8 (1.00) | TRPM8ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL22100712 | 0.73 | TRPM8 (0.82) | TRPM8ALDH1A1MAPTKDM4EPOLB | |
| SCHEMBL457033 | 0.73 | NFE2L2 (0.79) | TRPM8NFE2L2ALDH1A1MAPTKDM4E | |
| SCHEMBL6776487 | 0.73 | NFE2L2 (0.79) | TRPM8NFE2L2ALDH1A1MAPTKDM4E | |
| SCHEMBL1056670 | 0.73 | NFE2L2 (0.79) | TRPM8NFE2L2ALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2501761-B1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2020-06-17 | — | — | EP | disclosed |