Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 17/20 | 0.64 |
| ▸ | RAB9A | P51151 | 13/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 13/20 | 0.64 |
| ▸ | NPC1 | O15118 | 12/20 | 0.64 |
| ▸ | GAA | P10253 | 12/20 | 0.64 |
| ▸ | MEN1 | O00255 | 12/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 4/20 | 0.61 |
| ▸ | RELA | Q04206 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1165591 | 0.82 | MAPT (0.68) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL1165592 | 0.82 | MAPT (0.68) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL1231354 | 0.81 | MAPT (0.70) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL1231353 | 0.81 | MAPT (0.70) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL13779288 | 0.81 | MAPT (0.75) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL21010612 | 0.81 | MAPT (0.68) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL10038665 | 0.78 | MAPT (0.65) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL18873374 | 0.78 | MAPT (0.61) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL1164671 | 0.77 | MBD2 (0.65) | MAPTRAB9AKMT2ANPC1GAA | |
| SCHEMBL1164673 | 0.77 | MBD2 (0.65) | MAPTRAB9AKMT2ANPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020123675-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF CANCER | DUKE UNIVERSITY (US) | 2020-06-18 | — | — | WO | disclosed |