Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | S100A4 | P26447 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1281710 | 0.89 | ALDH1A1 (0.56) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL29706644 | 0.89 | ALDH1A1 (0.68) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL2783704 | 0.89 | ALDH1A1 (0.68) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| Nitrogen SCHEMBL28731041 | 0.85 | ALDH1A1 (0.63) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL240605 | 0.85 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL222175 | 0.85 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL153660 | 0.85 | ALDH1A1 (0.48) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL11756234 | 0.85 | ALDH1A1 (0.53) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| SCHEMBL4264263 | 0.85 | ERN1 (0.51) | ALDH1A1CYP3A4CTSBERN1MAPT | |
| Bromide SCHEMBL18614480 | 0.83 | ERN1 (0.50) | ALDH1A1CYP3A4CTSBERN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865912-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-10-21 | — | — | US | claimed |
| US-20140142321-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | GLAXOSMITHKLINE LLC (US) | 2014-05-22 | — | — | US | claimed |
| CN-113544129-B | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2024-07-23 | — | — | CN | disclosed |
| CN-113544129-A | Tricyclic compound preparation method and application thereof in medicine field | 上海华汇拓医药科技有限公司 | 2021-10-22 | — | — | CN | disclosed |
| EP-3831383-A1 | BROMODOMAIN INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2021-06-09 | — | — | EP | disclosed |
| EP-3283077-B1 | BROMODOMAIN INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2021-03-10 | — | — | EP | disclosed |
| US-10807982-B2 | Bromodomain inhibitors | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-10-20 | — | — | US | disclosed |
| WO-2020200284-A1 | PREPARATION METHOD FOR TRICYCLIC COMPOUND AND USE OF SAME IN FIELD OF MEDICINE | 上海华汇拓医药科技有限公司 | 2020-10-08 | — | — | WO | disclosed |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2020-05-26 | — | — | US | disclosed |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2020-05-26 | — | — | US | disclosed |
| US-20200071332-A1 | BROMODOMAIN INHIBITORS | CELGENE QUANTICEL RESEARCH, INC. (US) | 2020-03-05 | — | — | US | disclosed |
| US-20090197877-A1 | Antibacterial Compositions | PROLYSIS LTD. (GB) | 2009-08-06 | — | — | US | disclosed |
| CN-101472585-A | Antibacterial compositions | PROLYSIS LTD (GB) | 2009-07-01 | — | — | CN | disclosed |
| EP-2034997-A1 | ANTIBACTERIAL COMPOSITIONS | Prolysis Limited (GB) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007148093-A1 | ANTIBACTERIAL COMPOSITIONS | PROLYSIS LTD. (GB) | 2007-12-27 | — | — | WO | disclosed |
| WO-2007148093-A1 | ANTIBACTERIAL COMPOSITIONS | PROLYSIS LTD. (GB) | 2007-12-27 | — | — | WO | disclosed |
| US-20060194969-A1 | 4-Substituted benzimidazoles and their uses as inhibitors of gastric secretion | ALTANA PHARMA AG (DE) | 2006-08-31 | — | — | US | disclosed |
| EP-1575924-A1 | 4-SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS INHIBITORS OF GASTRIC SECRETION | ALTANA Pharma AG (DE) | 2005-09-21 | — | — | EP | disclosed |
| WO-2004054984-A1 | 4-SUBSTITUTED BENZIMIDAZOLES AND THEIR USE AS INHIBITORS OF GASTRIC SECRETION | ALTANA PHARMA AG (DE) | 2004-07-01 | — | — | WO | disclosed |
| US-5030241-A | Providing yellow and orange shades, with or without oxidation agent | WELLA AKTIENGESELLSCHAFT (DE) | 1991-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200071332-A1 | BROMODOMAIN INHIBITORS | BRD3, EP300, BRPF3 | ALDH1A1 3316/4885CYP3A4 4794/4885CTSB 2488/4885 |
| US-20090197877-A1 | Antibacterial Compositions | CYCS, COX6C, INTS6 | ALDH1A1 3469/4885CYP3A4 849/4885CTSB 3753/4885 |
| US-20140142321-A1 | Benzimidazole Derivatives As PI3 Kinase Inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885CYP3A4 1332/4885CTSB 1715/4885 |
| US-10807982-B2 | Bromodomain inhibitors | BRD3, EP300, BRPF3 | ALDH1A1 3316/4885CYP3A4 4794/4885CTSB 2488/4885 |
| US-20060194969-A1 | 4-Substituted benzimidazoles and their uses as inhibitors of gastric secretion | GIPR, VIP, SI | ALDH1A1 576/4885CYP3A4 21/4885CTSB 852/4885 |
| US-10660898-B2 | Benzimidazole derivatives as PI3 kinase inhibitors | PI4KB, PIK3CD, PI4KA | ALDH1A1 1375/4885CYP3A4 1332/4885CTSB 1715/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.