SCHEMBL222175

SCHEMBL222175

Nc1c(I)cc(Br)cc1[N+](=O)[O-]

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.48
CYP3A4 P08684 2/20 0.48
CTSB P07858 1/20 0.43
ERN1 O75460 1/20 0.43
XDH P47989 1/20 0.42
S100A4 P26447 1/20 0.40
TRPV1 Q8NER1 1/20 0.40
PARP1 P09874 1/20 0.40
LMNA P02545 1/20 0.40
TDP1 Q9NUW8 4/20 0.38
MAPT P10636 3/20 0.38
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
TSHR P16473 2/20 0.38
POLB P06746 1/20 0.38
ALOX15 P16050 1/20 0.38
KDM4E B2RXH2 1/20 0.38
G6PD P11413 1/20 0.38
PKM P14618 1/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL221077 0.85 ALDH1A1 (0.57) ALDH1A1CYP3A4CTSBERN1S100A4
SCHEMBL11749582 0.82 ALDH1A1 (0.46) ALDH1A1CYP3A4CTSBXDHPARP1
SCHEMBL7032612 0.80 ALDH1A1 (0.63) ALDH1A1CYP3A4XDHLMNATDP1
SCHEMBL1281710 0.79 ALDH1A1 (0.56) ALDH1A1CYP3A4CTSBERN1S100A4
SCHEMBL2783704 0.79 ALDH1A1 (0.68) ALDH1A1CYP3A4CTSBERN1S100A4
SCHEMBL29706644 0.79 ALDH1A1 (0.68) ALDH1A1CYP3A4CTSBERN1S100A4
SCHEMBL4704860 0.78 ALDH1A1 (0.43) ALDH1A1CYP3A4CTSBXDHPARP1
SCHEMBL17770642 0.78 CYP1A2 (0.52) ALDH1A1CYP3A4ERN1S100A4TRPV1
SCHEMBL3011561 0.78 ALDH1A1 (0.43) ALDH1A1CYP3A4CTSBXDHPARP1
SCHEMBL31423032 0.78 CYP1A2 (0.52) ALDH1A1CYP3A4ERN1S100A4TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 80 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720057-A2 COMPOUNDS AND COMPOSITIONS AS CBP/P300 DEGRADERS AND USES THEREOF Oncopia Therapeutics, Inc. D/B/A SK Life Science Labs (US) 2026-04-08 EP disclosed
EP-4656629-A1 INDOLE DERIVATIVE WITH SUBSTITUENT AND PHARMACEUTICAL USE MitoImmune Therapeutics Inc. (KR) 2025-12-03 EP disclosed
US-20250186433-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF EPIVARIO, INC. 2025-06-12 US disclosed
EP-4097099-B9 HETEROCYCLIC GLP-1 AGONISTS GASHERBRUM BIO INC (US) 2025-04-30 EP disclosed
CN-119874775-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-04-25 CN disclosed
CN-119841865-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-04-18 CN disclosed
CN-119823184-A Heterocyclic GLP-1 agonists 加舒布鲁姆生物公司 2025-04-15 CN disclosed
EP-4524135-A1 KINESIN KIF18A INHIBITOR AND USE THEREOF Shanghai Apeiron Therapeutics Company Limited (CN) 2025-03-19 EP disclosed
CN-119212988-A Kinesin KIF18A inhibitor and application thereof 上海湃隆生物科技有限公司 2024-12-27 CN disclosed
CN-119143752-A Aminoquinoline derivative, pharmaceutical composition containing same, preparation method and application thereof 四川科伦博泰生物医药股份有限公司 2024-12-17 CN disclosed
US-7977340-B2 Antibacterial compositions PROLYSIS LTD. (GB) 2011-07-12 US disclosed
US-7977340-B2 Antibacterial compositions PROLYSIS LTD. (GB) 2011-07-12 US disclosed
US-7977340-B2 Antibacterial compositions PROLYSIS LTD. (GB) 2011-07-12 US disclosed
US-20090197877-A1 Antibacterial Compositions PROLYSIS LTD. (GB) 2009-08-06 US disclosed
US-20090197877-A1 Antibacterial Compositions PROLYSIS LTD. (GB) 2009-08-06 US disclosed
US-20090197877-A1 Antibacterial Compositions PROLYSIS LTD. (GB) 2009-08-06 US disclosed
CN-101472585-A Antibacterial compositions PROLYSIS LTD (GB) 2009-07-01 CN disclosed
EP-2034997-A1 ANTIBACTERIAL COMPOSITIONS Prolysis Limited (GB) 2009-03-18 EP disclosed
WO-2007148093-A1 ANTIBACTERIAL COMPOSITIONS PROLYSIS LTD. (GB) 2007-12-27 WO disclosed
US-4053527-A REACTING HALONITROANILINES WITH ALCOHOLS AND NITROSATING AGENTS ION BASF AKTIENGESELLSCHAFT (DT) 1977-10-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250186433-A1 ACSS2 INHIBITORS AND METHODS OF USE THEREOF ACSS2, GLS2, ADSS2 ALDH1A1 238/4885CYP3A4 3671/4885CTSB 460/4885
US-20090197877-A1 Antibacterial Compositions CYCS, COX6C, INTS6 ALDH1A1 3469/4885CYP3A4 849/4885CTSB 3753/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.