⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9302567 | 0.72 | — | — | |
| SCHEMBL10695440 | 0.72 | CA2 (0.36) | — | |
| SCHEMBL1637380 | 0.70 | — | — | |
| SCHEMBL5502149 | 0.69 | — | — | |
| SCHEMBL8149461 | 0.65 | CA2 (0.35) | — | |
| Sulfuric Acid SCHEMBL25293539 | 0.63 | CA5A (0.43) | — | |
| Sulfuric Acid SCHEMBL921995 | 0.63 | — | — | |
| Sulfuric Acid SCHEMBL3951699 | 0.61 | ALDH1A1 (0.60) | — | |
| Sulfuric Acid SCHEMBL11600145 | 0.61 | CA5A (0.40) | — | |
| Sulfuric Acid SCHEMBL3086372 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016176560-A1 | CHROMIUM-MEDIATED COUPLING AND APPLICATION TO THE SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | WO | claimed |
| EP-1280753-A1 | PROCESS FOR PREPARATION OF R-1-(ARYLOXY)PROPAN-2-OL | Rhodia/Chirex, Inc. (US) | 2003-02-05 | — | — | EP | claimed |
| US-6448449-B2 | RING OPENING OF (R)-PROPYLENE OXIDE WITH ARYLTRIMETHYLSILYL ETHER IN THE PRESENCE OF AN OPTICALLY ACTIVE CATALYST; REACTING WITH AN ALCOHOL IN THE PRESENCE OF AN ACID; REACTING THE REGIOISOMERIC MIXTURE WITH A TRIARYLMETHYL HALILE; | RHODIA CHIREX, INC. | 2002-09-10 | — | — | US | claimed |
| US-20020007090-A1 | Process for preparation of (R)-1- (aryloxy)propan-2-ol | RHODIA CHIREX, INC. | 2002-01-17 | — | — | US | claimed |
| WO-2001081286-A1 | PROCESS FOR PREPARATION OF R-1-(ARYLOXY)PROPAN-2-OL | RHODIA/CHIREX, INC. (US) | 2001-11-01 | — | — | WO | claimed |
| JP-9012537-A | — | — | None | — | — | JP | disclosed |
| JP-8325259-A | — | — | None | — | — | JP | disclosed |
| CN-111433211-B | Synthesis of halichondrin | 哈佛大学的校长及成员们 | 2024-05-07 | — | — | CN | disclosed |
| US-20230128195-A1 | SYNTHESIS OF HALICHONDRINS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-04-27 | — | — | US | disclosed |
| EP-4169924-A2 | SYNTHESIS OF HALICHONDRINS | President And Fellows Of Harvard College (US) | 2023-04-26 | — | — | EP | disclosed |
| US-11548898-B2 | Synthesis of halichondrins | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-01-10 | — | — | US | disclosed |
| EP-3649135-B1 | SYNTHESIS OF HALICHONDRINS | HARVARD COLLEGE (US) | 2022-12-28 | — | — | EP | disclosed |
| WO-2001081286-A1 | PROCESS FOR PREPARATION OF R-1-(ARYLOXY)PROPAN-2-OL | RHODIA/CHIREX, INC. (US) | 2001-11-01 | — | — | WO | disclosed |
| US-5705702-A | REACTING AN ARYL GRIGNARD REAGENT WITH THIONYL CHLORIDE, THEN WITH TRIORGANOSILYL SULFONATE OR TRIORGANOSILYLHALIDE | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| JP-H0912537-A | SULFONIUM SALT | SHIN ETSU CHEM CO LTD | 1997-01-14 | — | — | JP | disclosed |
| JP-H08325259-A | SULFONIUM SALT AND CHEMICAL AMPLIFICATION-TYPE POSITIVE-TYPE RESIST MATERIAL | SHIN ETSU CHEM CO LTD | 1996-12-10 | — | — | JP | disclosed |
| EP-0403600-A4 | DEPROTECTION OF PROTECTED PEPTIDES | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0403600-A1 | DEPROTECTION OF PROTECTED PEPTIDES | THE ROCKEFELLER UNIVERSITY (US) | 1990-12-27 | — | — | EP | disclosed |
| WO-1990002138-A1 | DEPROTECTION OF PROTECTED PEPTIDES | THE ROCKEFELLER UNIVERSITY (US) | 1990-03-08 | — | — | WO | disclosed |
| JP-H00912537-A | — | — | 0001-01-01 | — | — | JP | disclosed |