Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215224 | 0.93 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2RECQLPOLBKDM4E | |
| SCHEMBL1992679 | 0.77 | MEN1 (0.43) | ALDH1A1SMN1; SMN2RECQLPOLBKDM4E | |
| SCHEMBL2212160 | 0.76 | ACACB (0.41) | ALDH1A1SMN1; SMN2KDM4EHPGDMAPT | |
| SCHEMBL2990475 | 0.72 | ADORA3 (0.42) | ALDH1A1SMN1; SMN2POLBKDM4EHPGD | |
| SCHEMBL31647297 | 0.72 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2RECQLPOLBKDM4E | |
| SCHEMBL18892251 | 0.72 | KDM4E (0.57) | ALDH1A1SMN1; SMN2KDM4ELMNAMAPK1 | |
| SCHEMBL27599861 | 0.72 | L3MBTL1 (0.40) | ALDH1A1KDM4ELMNAHPGDMAPT | |
| SCHEMBL16505479 | 0.71 | KDM4E (0.56) | ALDH1A1SMN1; SMN2POLBKDM4EMAPK1 | |
| SCHEMBL7983660 | 0.71 | ALDH1A1 (0.53) | ALDH1A1SMN1; SMN2RECQLPOLBKDM4E | |
| SCHEMBL27529060 | 0.70 | RAD52 (0.44) | ALDH1A1SMN1; SMN2RECQLPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490355-B1 | INDOLYLMALEIMIDE DERIVATIVES | NOVARTIS AG (CH) | 2011-07-27 | — | — | EP | disclosed |
| US-7534808-B2 | Indolylmaleimide derivatives | ELANCO TIERGESUNDHEIT AG (CH) | 2009-05-19 | — | — | US | disclosed |
| US-20050119274-A1 | Indolylmaleimide derivatives | NOVARTIS AG (CH) | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119274-A1 | Indolylmaleimide derivatives | MYLK2, DGKK, LCK | ALDH1A1 3744/4885SMN1; SMN2 1884/4885RECQL 4029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.