Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 9/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | SMO | Q99835 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.33 |
| ▸ | KHK | P50053 | 1/20 | 0.32 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22129464 | 0.81 | SMO (0.41) | SMO | |
| SCHEMBL22153061 | 0.79 | PDE9A (0.41) | RETARSMOKDM4EALDH1A1 | |
| SCHEMBL22153065 | 0.77 | JAK2 (0.36) | RETARSMOKDM4EALDH1A1 | |
| SCHEMBL23955998 | 0.74 | EGLN2 (0.39) | RETAR | |
| SCHEMBL23044980 | 0.73 | MCHR1 (0.35) | SMOHCRTR1HCRTR2 | |
| SCHEMBL22129474 | 0.69 | PDE10A (0.46) | — | |
| SCHEMBL28894986 | 0.68 | RET (0.32) | RETKCNJ1 | |
| SCHEMBL19145260 | 0.68 | ALDH1A1 (0.51) | RETARKDM4EALDH1A1MAPT | |
| SCHEMBL29227963 | 0.67 | ACACB (0.39) | KDM4ESMN1; SMN2 | |
| SCHEMBL20575496 | 0.67 | JAK2 (0.46) | RETAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111333626-B | Phenyl pyrrolidine compounds and uses thereof | 武汉人福创新药物研发中心有限公司 | 2022-10-18 | — | — | CN | disclosed |
| CN-111333626-A | Phenyl pyrrolidine compounds and uses thereof | 湖北生物医药产业技术研究院有限公司 | 2020-06-26 | — | — | CN | disclosed |
| WO-2020125627-A1 | PHENYLPYRROLIDINE COMPOUND AND USE THEREOF | 湖北生物医药产业技术研究院有限公司 | 2020-06-25 | — | — | WO | disclosed |