Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1754132 | 0.82 | ALDH1A1 (0.58) | ESR1THRATHRBALDH1A1TSHR | |
| SCHEMBL126012 | 0.81 | ALDH1A1 (0.44) | ALDH1A1TSHRCYP3A4MAPK1TDP1 | |
| SCHEMBL18364998 | 0.80 | ALDH1A1 (0.39) | ALDH1A1TSHRCYP3A4MAPK1TDP1 | |
| SCHEMBL22030471 | 0.79 | HRH3 (0.38) | ALDH1A1TSHRCYP3A4MAPK1TDP1 | |
| SCHEMBL10294040 | 0.78 | PPARG (0.39) | ALDH1A1TSHRCYP3A4MAPK1TDP1 | |
| SCHEMBL6685103 | 0.78 | ESR1 (0.74) | ESR1THRATHRBALDH1A1TSHR | |
| SCHEMBL21100336 | 0.76 | ESR1 (0.64) | ESR1THRATHRBSLC6A4HRH3 | |
| SCHEMBL21566931 | 0.75 | ESR1 (0.47) | ESR1THRATHRBALDH1A1TSHR | |
| SCHEMBL10294021 | 0.75 | ALDH1A1 (0.56) | THRBALDH1A1TSHRCYP3A4MAPK1 | |
| SCHEMBL23504661 | 0.74 | NUDT1 (0.33) | ALDH1A1TSHRALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11779649-B2 | Antibodies to PMEL17 and conjugates thereof | NOVARTIS AG (CH) | 2023-10-10 | — | — | US | disclosed |
| US-20200197528-A1 | ANTIBODIES TO PMEL17 AND CONJUGATES THEREOF | NOVARTIS AG (CH) | 2020-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11779649-B2 | Antibodies to PMEL17 and conjugates thereof | GNA15, GNA11, EEA1 | ESR1 3287/4885THRA 3239/4885THRB 3721/4885 |
| US-20200197528-A1 | ANTIBODIES TO PMEL17 AND CONJUGATES THEREOF | GNA15, GNA11, EEA1 | ESR1 3445/4885THRA 3339/4885THRB 3863/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.