Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2215195 | 0.94 | MEN1 (0.45) | MAPTMEN1KMT2ATSHRTP53 | |
| SCHEMBL2214909 | 0.86 | LOXL2 (0.38) | MAPTTP53KDM4EALDH1A1GAA | |
| SCHEMBL2213715 | 0.86 | SMN1; SMN2 (0.38) | MAPTMEN1KMT2ATP53KDM4E | |
| SCHEMBL2214311 | 0.84 | KCNK9 (0.44) | MAPTMEN1KMT2ATP53KDM4E | |
| SCHEMBL2215156 | 0.84 | KDM4E (0.37) | MAPTMEN1KMT2ATP53KDM4E | |
| SCHEMBL2213042 | 0.84 | LMNA (0.37) | MAPTTP53KDM4EALDH1A1GAA | |
| SCHEMBL2215249 | 0.83 | SMN1; SMN2 (0.37) | MAPTMEN1KMT2ATSHRTP53 | |
| SCHEMBL2216183 | 0.82 | ALDH1A1 (0.42) | MAPTMEN1KMT2AKDM4EKCNK3 | |
| SCHEMBL2212145 | 0.82 | BRD4 (0.39) | MAPT | |
| SCHEMBL2215351 | 0.82 | AURKB (0.36) | MAPTMEN1KMT2ATP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |