Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | VHL | P40337 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26655212 | 0.81 | VHL (0.52) | AREPHX2VHLCYP3A4 | |
| SCHEMBL20116384 | 0.79 | GPR119 (0.47) | AREPHX2GPR119PPARANAMPT | |
| SCHEMBL13111226 | 0.79 | ALDH1A1 (0.51) | AREPHX2GPR119HDAC8OGA | |
| SCHEMBL14472426 | 0.78 | EPHX2 (0.43) | AREPHX2GPR119DPP4PPARA | |
| SCHEMBL7049069 | 0.78 | ALDH1A1 (0.59) | CYP3A4ALDH1A1LMNASCN5A | |
| SCHEMBL3931937 | 0.77 | ALDH1A1 (0.56) | EPHX2GPR119CYP3A4ALDH1A1LMNA | |
| SCHEMBL3929382 | 0.76 | GPR119 (0.56) | EPHX2GPR119OGAALDH1A1LMNA | |
| SCHEMBL13044948 | 0.74 | TACR1 (0.44) | HDAC8 | |
| SCHEMBL17973855 | 0.74 | TRPA1 (0.43) | EPHX2GPR119CYP3A4ALDH1A1LMNA | |
| SCHEMBL1668815 | 0.72 | SMN1; SMN2 (0.52) | EPHX2GPR119EGLN2CYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1808440-B1 | Non-covalent inhibitors of urokinase and blood vessel formation | WILEX AG (DE) | 2011-07-27 | — | — | EP | disclosed |
| EP-1808440-A1 | Non-covalent inhibitors of urokinase and blood vessel formation | Wilex AG (DE) | 2007-07-18 | — | — | EP | disclosed |
| EP-1182207-B1 | Non-covalent inhibitors of urokinase and blood vessel formation | DENDREON CORP (US) | 2007-04-18 | — | — | EP | disclosed |
| US-6586405-B2 | Therapy for blood disorders | CORVAS INTERNATIONAL, INC. | 2003-07-01 | — | — | US | disclosed |
| US-20020037857-A1 | Non-covalent inhibitors of urokinase and blood vessel formation | CORVAS INTERNATIONAL, INC. | 2002-03-28 | — | — | US | disclosed |
| EP-1182207-A2 | Non-covalent inhibitors of urokinase and blood vessel formation | CORVAS INTERNATIONAL, INC. (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2002014349-A2 | NON-COVALENT INHIBITORS OF UROKINASE AND BLOOD VESSEL FORMATION | CORVAS INTERNATIONAL, INC. (US) | 2002-02-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020037857-A1 | Non-covalent inhibitors of urokinase and blood vessel formation | PLAU, PLAT, PLG | AR 4363/4885EPHX2 1982/4885GPR119 1992/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.