Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT5 | Q96KN8 | 9/20 | 0.56 |
| ▸ | PLAAT4 | Q9UL19 | 9/20 | 0.56 |
| ▸ | PLAAT3 | P53816 | 8/20 | 0.56 |
| ▸ | PLAAT2 | Q9NWW9 | 8/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19425688 | 0.86 | PLAAT5 (0.49) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL15184416 | 0.85 | SMN1; SMN2 (0.55) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL8321028 | 0.84 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1HPGDMMP1MMP2 | |
| SCHEMBL10843414 | 0.82 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1NPC1RAB9ATAAR1 | |
| SCHEMBL10711293 | 0.82 | ALDH1A1 (0.73) | SMN1; SMN2ALDH1A1NPC1RAB9ATAAR1 | |
| SCHEMBL22412530 | 0.79 | PLAAT5 (0.75) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL25008046 | 0.79 | SMN1; SMN2 (0.74) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL10163215 | 0.76 | SMN1; SMN2 (0.66) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL4831685 | 0.76 | PLAAT5 (0.70) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 | |
| SCHEMBL24799994 | 0.76 | ALDH1A1 (0.52) | PLAAT5PLAAT4PLAAT3PLAAT2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022125849-A1 | PROGRANULIN MODULATORS AND METHODS OF USING THE SAME | ARKUDA THERAPEUTICS (US) | 2022-06-16 | — | — | WO | disclosed |
| US-11203582-B2 | Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2021-12-21 | — | — | US | disclosed |
| US-20200199094-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA | 2020-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200199094-A1 | BENZAMIDE DERIVATIVES FOR INHIBITING ENDOPLASMIC RETICULUM (ER) STRESS | HSPA5, TMBIM6, BAD | PLAAT5 924/4885PLAAT4 689/4885PLAAT3 601/4885 |
| US-11203582-B2 | Benzamide derivatives for inhibiting endoplasmic reticulum (ER) stress | HSPA5, TMBIM6, BAD | PLAAT5 924/4885PLAAT4 689/4885PLAAT3 601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.