Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.45 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | CTSV | O60911 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17736786 | 0.88 | ALDH1A1 (0.49) | LMNAMRGPRX4ALDH1A1TSHRSGMS2 | |
| SCHEMBL15763605 | 0.87 | FOLH1 (0.51) | MRGPRX4ALDH1A1SGMS2KDM4E | |
| SCHEMBL31037055 | 0.83 | LMNA (0.49) | LMNAHPGDMRGPRX4ALDH1A1USP2 | |
| SCHEMBL13662895 | 0.80 | LMNA (0.58) | LMNAHPGDALDH1A1USP2TSHR | |
| SCHEMBL1009498 | 0.80 | TSHR (0.48) | LMNAHPGDMAPK8ALDH1A1TSHR | |
| SCHEMBL24983869 | 0.79 | LMNA (0.56) | LMNAHPGDSGMS2SMPD1HDAC1 | |
| SCHEMBL22149137 | 0.79 | PTPN1 (0.46) | MRGPRX4CTSVCTSLMTNR1AMTNR1B | |
| SCHEMBL18827163 | 0.78 | GSK3B (0.51) | MAPK8MRGPRX4HDAC8KDM4EGAA | |
| SCHEMBL5683642 | 0.78 | HPGD (0.56) | LMNAHPGDALDH1A1USP2TSHR | |
| SCHEMBL9899201 | 0.78 | NR4A2 (0.46) | LMNAHPGDMAPK8ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898590-B1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-22 | — | — | EP | disclosed |
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-03-10 | — | — | US | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126033-A1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | LMNA 2683/4885HPGD 1161/4885MAPK8 4412/4885 |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | CCNH, CCNT1, PAH | LMNA 596/4885HPGD 2284/4885MAPK8 2433/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.