Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22163294 | 0.93 | MAOB (0.49) | MAPTGAAHDAC1SGMS2SMN1; SMN2 | |
| SCHEMBL22163084 | 0.90 | TLR7 (0.49) | MAPTGAAHDAC1TLR7PPIA | |
| SCHEMBL22163295 | 0.88 | SMN1; SMN2 (0.50) | MAPTGAAHDAC1SMN1; SMN2KDM4E | |
| SCHEMBL22163296 | 0.88 | MAPT (0.52) | MAPTGAASMN1; SMN2KDM4EHTT | |
| SCHEMBL22163287 | 0.87 | PPIA (0.48) | MAPTGAAHDAC1SGMS2SMN1; SMN2 | |
| SCHEMBL22163293 | 0.87 | MAPT (0.53) | MAPTGAAHDAC1SGMS2KDR | |
| SCHEMBL22163288 | 0.84 | GRM4 (0.51) | MAPTGAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL24262933 | 0.83 | MAPT (0.48) | MAPTGAAHDAC1SGMS2SMN1; SMN2 | |
| SCHEMBL22148988 | 0.80 | PPIA (0.46) | MAPTGAASMN1; SMN2KDM4EKMT2A | |
| SCHEMBL22145142 | 0.78 | ALDH1A1 (0.48) | MAPTGAAKDRSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898590-B1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-22 | — | — | EP | disclosed |
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-03-10 | — | — | US | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126033-A1 | METHOD FOR PREPARING INDOLENAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | MAPT 1575/4885GAA 4335/4885HDAC1 804/4885 |
| US-20220073533-A1 | Method for Preparing Indolenaphthopyrans | CCNH, CCNT1, PAH | MAPT 2123/4885GAA 2695/4885HDAC1 671/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.