Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PPIA | P62937 | 1/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22149090 | 0.80 | MGLL (0.47) | NPC1RAB9AHPGDPTPN1MGLL | |
| SCHEMBL22145265 | 0.78 | MAPT (0.51) | ALDH1A1KDM4EKDRCYP1A2CYP2C9 | |
| SCHEMBL22145236 | 0.76 | LMNA (0.48) | ALDH1A1HPGDBRD4KDM4EGAA | |
| SCHEMBL11670391 | 0.75 | CREBBP (0.57) | NPC1RAB9AHPGDBRD4PTGER1 | |
| SCHEMBL15763605 | 0.75 | FOLH1 (0.51) | ALDH1A1PTGER1POLBKDM4E | |
| SCHEMBL11879436 | 0.74 | RAB9A (0.61) | ALDH1A1NPC1RAB9AHPGDBRD4 | |
| SCHEMBL15014407 | 0.74 | CYP2C9 (0.48) | NPC1RAB9ABRD4PTGER1CYP2C9 | |
| SCHEMBL17736786 | 0.74 | ALDH1A1 (0.49) | ALDH1A1NPC1RAB9APOLBMEN1 | |
| SCHEMBL9721922 | 0.73 | ALDH1A1 (0.61) | ALDH1A1NPC1RAB9AHPGDPOLB | |
| SCHEMBL2070523 | 0.73 | CYP19A1 (0.76) | ALDH1A1CYP1A2CYP2C9CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3898636-B9 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-11-08 | — | — | EP | disclosed |
| EP-3898636-B1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL LTD (IE) | 2023-08-30 | — | — | EP | disclosed |
| US-20220056039-A1 | Indolonaphthopyrans | TRANSITIONS OPTICAL, LTD. (IE) | 2022-02-24 | — | — | US | disclosed |
| WO-2020126032-A1 | INDOLONAPHTHOPYRANS | TRANSITIONS OPTICAL, LTD. (IE) | 2020-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220056039-A1 | Indolonaphthopyrans | TPH1, TPH2, IDO1 | ALDH1A1 230/4885NPC1 4095/4885RAB9A 3592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.