Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 12/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.50 |
| ▸ | OXTR | P30559 | 1/20 | 0.49 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.46 |
| ▸ | SPR | P35270 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2212100 | 0.89 | AVPR1A (0.61) | AVPR1AHRH4OXTRAVPR2HRH3 | |
| SCHEMBL2213556 | 0.88 | AVPR1A (0.60) | AVPR1AHRH4OXTRAVPR2SPR | |
| SCHEMBL606417 | 0.77 | HRH4 (0.81) | HRH4HRH3 | |
| SCHEMBL18889251 | 0.76 | HRH4 (0.60) | HRH4HRH3 | |
| SCHEMBL15963106 | 0.73 | AVPR1A (0.60) | AVPR1AOXTRAVPR2HRH3 | |
| SCHEMBL4357791 | 0.73 | AVPR1A (0.64) | AVPR1AOXTRAVPR2SPRHRH3 | |
| SCHEMBL3246900 | 0.73 | KMT2A (0.64) | AVPR1AHRH4OXTR | |
| SCHEMBL3253825 | 0.73 | AVPR1A (0.63) | AVPR1AHRH4OXTRHRH3 | |
| SCHEMBL6993813 | 0.72 | AVPR1A (0.59) | AVPR1AOXTRAVPR2HRH3 | |
| SCHEMBL15963086 | 0.72 | MGLL (0.52) | AVPR1AOXTRAVPR2SPRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7495008-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2009-02-24 | — | — | US | claimed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | claimed |
| EP-2125726-B1 | SPIRO-PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | disclosed |
| EP-2125726-B1 | SPIRO-PIPERIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2011-07-27 | — | — | EP | disclosed |
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| US-7678806-B2 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-03-16 | — | — | US | disclosed |
| EP-2125726-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-12-02 | — | — | EP | disclosed |
| US-7501432-B2 | Spiro-piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501432-B2 | Spiro-piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-7501432-B2 | Spiro-piperidine derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-03-10 | — | — | US | disclosed |
| US-20080280898-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-11-13 | — | — | US | disclosed |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | F. HOFFMANN-LA ROCHE AG, A SWISS COMPANY (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161304-A1 | Spiro-piperidine derivatives | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| WO-2008077811-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |
| WO-2008077811-A1 | SPIRO-PIPERIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161304-A1 | Spiro-piperidine derivatives | AVPR1A, AVPR1B, ADRA1A | AVPR1A 1/4885HRH4 241/4885OXTR 46/4885 |
| US-20080167333-A1 | NEW SOLID FORMS OF [4-(3-FLUORO-5-TRIFLUOROMETHYL-PYRIDIN-2-YL)-PIPERAZIN-1-YL-[5-METHANESULFONYL-2-((S)-2,2,2-TRIFLUORO-1-METHYL-ETHOXY)-PHENYL]-METHANONE | HTR1A, HTR5A, ADRA1A | AVPR1A 7/4885HRH4 151/4885OXTR 162/4885 |
| US-20080280898-A1 | Spiro-piperidine derivatives | AVPR1A, AVPR1B, ADRA1A | AVPR1A 1/4885HRH4 241/4885OXTR 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.