SCHEMBL2214839

SCHEMBL2214839

CC(=O)c1ccc(OCCCCC(=O)NC2CCN(Cc3ccc(Cl)c(Cl)c3)CC2)cc1

nearest known ligand 0.65

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 7/20 0.65
MCHR1 Q99705 2/20 0.59
SIGMAR1 Q99720 2/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
HRH3 Q9Y5N1 2/20 0.54
CCR1 P32246 1/20 0.50
CCR3 P51677 1/20 0.50
USP2 O75604 1/20 0.49
ADIPOR2 Q86V24 1/20 0.49
ADIPOR1 Q96A54 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2213070 0.97 UTS2R (0.64) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2211108 0.94 UTS2R (0.62) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2215875 0.89 SIGMAR1 (0.60) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2210339 0.89 ADIPOR2 (0.63) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2213240 0.88 USP2 (0.62) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL12511780 0.88 SIGMAR1 (0.61) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2208142 0.87 UTS2R (0.56) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2212156 0.85 SIGMAR1 (0.56) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2212835 0.85 MCHR1 (0.55) UTS2RMCHR1SIGMAR1MEN1KMT2A
SCHEMBL2212645 0.84 SIGMAR1 (0.53) UTS2RMCHR1SIGMAR1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1389616-B1 3,4-Dihalobenzylpiperidine derivatives and their medical use MITSUBISHI TANABE PHARMA CORP (JP) 2011-07-27 EP disclosed
US-7115635-B2 Benzylpiperidine compound MITSUBISHI PHARMA CORPORATION (JP) 2006-10-03 US disclosed
US-20040158071-A1 Chemokine inhibitors and stability in blood MITSUBISHI PHARMA CORPORATION (JP) 2004-08-12 US disclosed
EP-1389616-A1 NOVEL BENZYLPIPERIDINE COMPOUND Mitsubishi Pharma Corporation (JP) 2004-02-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040158071-A1 Chemokine inhibitors and stability in blood CCL2, CXCR1, CCR5 UTS2R 2154/4885MCHR1 1048/4885SIGMAR1 2000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.