Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.37 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 5/20 | 0.36 |
| ▸ | ITGA2 | P17301 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213794 | 0.97 | ROCK2 (0.40) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2215043 | 0.95 | F2 (0.39) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2214272 | 0.92 | MAP3K5 (0.39) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2216183 | 0.85 | ALDH1A1 (0.42) | ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL2212315 | 0.84 | MAPT (0.41) | ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL2214233 | 0.84 | DNMT1 (0.42) | F2ALDH1A1HPGDSMN1; SMN2HSD17B10 | |
| SCHEMBL2215221 | 0.84 | MAPT (0.42) | ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL2215080 | 0.83 | LMNA (0.50) | ALDH1A1HPGDSMN1; SMN2HSD17B10KDM4E | |
| SCHEMBL2215111 | 0.83 | F2 (0.40) | F2PLGPLAUPLATKLKB1 | |
| SCHEMBL2213296 | 0.83 | JAK2 (0.39) | ROCK2MAP3K5MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797096-B1 | PYRAZOLOPYRIMIDINES AS INHIBITORS OF PROTEIN KINASE B (AKT) | BAYER SCHERING PHARMA AG (DE) | 2011-07-27 | — | — | EP | disclosed |