Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 8/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 5/20 | 0.35 |
| ▸ | CNR1 | P21554 | 4/20 | 0.35 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22152483 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2GAACNR2CNR1PRPS1 | |
| SCHEMBL22152186 | 0.83 | SMN1; SMN2 (0.35) | SMN1; SMN2GAACNR2CNR1 | |
| SCHEMBL22122260 | 0.82 | SMN1; SMN2 (0.35) | SMN1; SMN2GAA | |
| SCHEMBL22152008 | 0.81 | DUT (0.40) | SMN1; SMN2GAACNR2CNR1PRPS1 | |
| SCHEMBL22152194 | 0.81 | KAT2B (0.37) | SMN1; SMN2GAA | |
| SCHEMBL22155669 | 0.81 | KAT2B (0.37) | SMN1; SMN2GAA | |
| SCHEMBL22122439 | 0.81 | SMN1; SMN2 (0.34) | KDM1ASMN1; SMN2GAA | |
| SCHEMBL26673748 | 0.80 | NR1D1 (0.35) | SMN1; SMN2GAA | |
| SCHEMBL22122269 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2GAA | |
| SCHEMBL22122325 | 0.78 | SMN1; SMN2 (0.33) | SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020132597-A1 | COMPOUNDS THAT PARTICIPATE IN COOPERATIVE BINDING AND USES THEREOF | Revolution Medicines, Inc. (US) | 2020-06-25 | — | — | WO | disclosed |