Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.50 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.49 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29562227 | 1.00 | GABRA5 (0.57) | GABRA5POLBSMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL14659339 | 0.87 | GABRA5 (0.49) | GABRA5POLBSMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL1547274 | 0.86 | HSPB1 (0.63) | POLBSMN1; SMN2MAPTCYP19A1MEN1 | |
| SCHEMBL3368258 | 0.85 | HSPB1 (0.65) | GABRA5POLBSMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL18429692 | 0.85 | GAA (0.50) | GABRA5SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL29151276 | 0.85 | GABRA5 (0.52) | GABRA5MAPTCYP19A1MEN1KMT2A | |
| SCHEMBL11191676 | 0.85 | GAA (0.50) | GABRA5SMN1; SMN2MAPTCYP19A1MEN1 | |
| SCHEMBL15399370 | 0.84 | CYP19A1 (0.56) | GABRA5POLBSMN1; SMN2MAPTCYP19A1 | |
| SCHEMBL4413161 | 0.83 | HSPB1 (0.54) | GABRA5POLBSMN1; SMN2MAPTMEN1 | |
| SCHEMBL19834587 | 0.83 | HSPB1 (0.52) | POLBSMN1; SMN2MAPTCYP19A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278965-A1 | NOVEL CARBONOHYDRAZONOYL DICYANIDE COMPOUNDS COMPRISING 2 OR MORE ARYL OR HETEROARYL CONNECTED VIA LINKER AND USE THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2023-09-07 | — | — | US | disclosed |
| EP-4169916-A1 | CARBONOHYDRAZONOYL DICYANIDE COMPOUND INCLUDING AT LEAST TWO TYPES OF ARYL OR HETEROARYL LINKED BY NOVEL LINKER, AND USE THEREOF | Korea Institute of Science and Technology (KR) | 2023-04-26 | — | — | EP | disclosed |
| CN-115955968-A | Carbohydrazone acyldinitrile compounds comprising at least two aryl or heteroaryl groups connected by a novel linker and uses thereof | 韩国科学技术研究院 | 2023-04-11 | — | — | CN | disclosed |
| CN-109689652-B | Fused heterocyclic derivative, preparation method and medical application thereof | 北京诺诚健华医药科技有限公司 | 2022-04-26 | — | — | CN | disclosed |
| WO-2021256902-A1 | CARBONOHYDRAZONOYL DICYANIDE COMPOUND INCLUDING AT LEAST TWO TYPES OF ARYL OR HETEROARYL LINKED BY NOVEL LINKER, AND USE THEREOF | 한국과학기술연구원 | 2021-12-23 | — | — | WO | disclosed |
| US-11046682-B2 | Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2021-06-29 | — | — | US | disclosed |
| EP-3505517-A1 | FUSED HETEROCYCLIC DERIVATIVE, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | Beijing InnoCare Pharma Tech Co., Ltd. (CN) | 2019-07-03 | — | — | EP | disclosed |
| US-20190185472-A1 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF | BEIJING INNOCARE PHARMA TECH CO., LTD. (CN) | 2019-06-20 | — | — | US | disclosed |
| CN-109689652-A | Fused heterocycle derivative, preparation method and its application medically | 北京诺诚健华医药科技有限公司 | 2019-04-26 | — | — | CN | disclosed |
| EP-2225223-B1 | ORGANIC COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2017-01-11 | — | — | EP | disclosed |
| US-20080255124-A1 | Chemical Compounds | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | US | disclosed |
| EP-1809275-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006044707-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
| CN-1025998-C | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-09-28 | — | — | CN | disclosed |
| EP-0379314-B1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER (US) | 1994-03-23 | — | — | EP | disclosed |
| US-5169947-A | 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5051412-A | Pharmaceutically active 3-(1,2,5,6-tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1991-09-24 | — | — | US | disclosed |
| CN-1044465-A | 3-(1,2,5, the 6-tetrahydro pyridyl)-pyrrolopyridine | PFIZER (US) | 1990-08-08 | — | — | CN | disclosed |
| WO-1990007926-A1 | 3-(1,2,5,6-TETRAHYDROPYRIDYL)-PYRROLOPYRIDINES | PFIZER INC. (US) | 1990-07-26 | — | — | WO | disclosed |
| EP-0379314-A1 | 3-(1,2,5,6-Tetrahydropyridyl)-pyrrolopyridines | PFIZER INC. (US) | 1990-07-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230278965-A1 | NOVEL CARBONOHYDRAZONOYL DICYANIDE COMPOUNDS COMPRISING 2 OR MORE ARYL OR HETEROARYL CONNECTED VIA LINKER AND USE THEREOF | AADAC, CBR3, MTCL3 | GABRA5 1867/4885POLB 4215/4885SMN1; SMN2 4675/4885 |
| US-20190185472-A1 | FUSED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION METHODS THEREOF AND MEDICAL USES THEREOF | IDO1, IDO2, INMT | GABRA5 1547/4885POLB 4274/4885SMN1; SMN2 3030/4885 |
| US-20080255124-A1 | Chemical Compounds | NR3C2, NR5A1, NR3C1 | GABRA5 324/4885POLB 4278/4885SMN1; SMN2 4885/4885 |
| US-11046682-B2 | Fused heterocyclic derivatives, their preparation methods thereof and medical uses thereof | IDO1, IDO2, INMT | GABRA5 1547/4885POLB 4274/4885SMN1; SMN2 3030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.