Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 1/20 | 0.35 |
| ▸ | PYGL | P06737 | 1/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.31 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.31 |
| ▸ | S1PR5 | Q9H228 | 3/20 | 0.31 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.31 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | MC4R | P32245 | 1/20 | 0.30 |
| ▸ | MC5R | P33032 | 1/20 | 0.30 |
| ▸ | MC3R | P41968 | 1/20 | 0.30 |
| ▸ | MC1R | Q01726 | 1/20 | 0.30 |
| ▸ | PLG | P00747 | 1/20 | 0.30 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20026814 | 0.88 | PYGL (0.34) | PRCPPYGLACKR3ITGA4ITGB7 | |
| SCHEMBL17834564 | 0.87 | PYGL (0.41) | PRCPPYGLITGA4ITGB7ITGB1 | |
| SCHEMBL22167263 | 0.86 | S1PR4 (0.38) | PRCPPYGLACKR3ITGA4ITGB7 | |
| SCHEMBL16295882 | 0.86 | PYGL (0.38) | PRCPPYGLITGA4ITGB7ITGB1 | |
| SCHEMBL16343488 | 0.86 | PYGL (0.38) | PRCPPYGLITGA4ITGB7ITGB1 | |
| SCHEMBL16294409 | 0.85 | ITGB3 (0.38) | PRCPPYGLS1PR1S1PR4S1PR5 | |
| SCHEMBL16343238 | 0.85 | ITGB3 (0.38) | PRCPPYGLS1PR1S1PR4S1PR5 | |
| SCHEMBL16305700 | 0.85 | S1PR4 (0.39) | PRCPPYGLITGA4ITGB7S1PR1 | |
| SCHEMBL17834771 | 0.85 | S1PR1 (0.39) | PRCPPYGLACKR3ITGA4ITGB7 | |
| SCHEMBL16306128 | 0.84 | ITGB1 (0.39) | PRCPPYGLITGA4ITGB7ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3172199-B1 | PYRIMIDINE DERIVATIVES AS GLP-1 RECEPTOR MODULATORS | CELGENE INT II SARL (CH) | 2020-07-01 | — | — | EP | disclosed |