Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.48 |
| ▸ | CACNA1I | Q9P0X4 | 6/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | HTR4 | Q13639 | 3/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25089654 | 0.94 | EPHX1 (0.46) | EPHX1EPHX2CACNA1IKCNH2HTR4 | |
| SCHEMBL22169792 | 0.94 | EPHX1 (0.52) | EPHX1EPHX2CACNA1IKCNH2KDM4E | |
| SCHEMBL24865985 | 0.90 | EPHX1 (0.41) | EPHX1EPHX2CACNA1IKCNH2HTR4 | |
| SCHEMBL26330243 | 0.87 | HTR4 (0.41) | EPHX1EPHX2CACNA1IKCNH2HTR4 | |
| SCHEMBL25089651 | 0.87 | HSD11B1 (0.45) | EPHX1EPHX2CACNA1IKCNH2HTR4 | |
| SCHEMBL16771662 | 0.85 | TP53 (0.46) | EPHX1EPHX2CACNA1IKCNH2KDM4E | |
| SCHEMBL22302358 | 0.83 | EPHX1 (0.51) | EPHX1EPHX2CACNA1IKCNH2HTR4 | |
| SCHEMBL22302357 | 0.82 | HTR4 (0.43) | EPHX1EPHX2CACNA1IKCNH2HTR4 | |
| SCHEMBL9891801 | 0.81 | MAPT (0.44) | EPHX1EPHX2DPP4PREPFAP | |
| SCHEMBL25089683 | 0.77 | HTR4 (0.41) | EPHX1EPHX2CACNA1IKCNH2HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020160196-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |
| WO-2020160198-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2020-08-06 | — | — | WO | disclosed |