Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | TPMT | P51580 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | POLB | P06746 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31607313 | 0.80 | XDH (0.43) | NPSR1ABL1VCAM1CYP2C19MAPT | |
| SCHEMBL31607308 | 0.80 | NPSR1 (0.39) | NPSR1ABL1THRBCYP2C19MAPT | |
| SCHEMBL17200396 | 0.79 | MAPT (0.46) | NPSR1ABL1VCAM1THRBCYP2C19 | |
| SCHEMBL17200450 | 0.76 | NPSR1 (0.51) | NPSR1CYP2C19MAPTPOLBMEN1 | |
| SCHEMBL21487341 | 0.70 | GPR35 (0.46) | MAPTMEN1KMT2ATDP1MAPK1 | |
| SCHEMBL21695794 | 0.70 | MAPT (0.36) | ABL1VCAM1TPMTMAPTPOLB | |
| SCHEMBL25955952 | 0.68 | ALDH1A1 (0.35) | VCAM1MAPTTDP1MAPK1 | |
| SCHEMBL21808120 | 0.65 | ABL1 (0.52) | NPSR1ABL1VCAM1MAPTPOLB | |
| SCHEMBL29832511 | 0.65 | ABL1 (0.52) | NPSR1ABL1VCAM1MAPTPOLB | |
| SCHEMBL23123715 | 0.65 | NPSR1 (0.60) | NPSR1MAPTMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4218766-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Holdings Corporation (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3674302-A1 | 1H-PYRROLO[2,3-C]PYRIDIN-7(6H)-ONES AND PYRAZOLO[3,4-C]PYRIDIN-7(6H)-ONES AS INHIBITORS OF BET PROTEINS | Incyte Corporation (US) | 2020-07-01 | — | — | EP | disclosed |