Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837056 | 0.87 | — | — | |
| SCHEMBL835013 | 0.75 | — | — | |
| SCHEMBL8445734 | 0.68 | TSHR (0.38) | TSHR | |
| SCHEMBL760066 | 0.68 | TSHR (0.38) | TSHR | |
| SCHEMBL6693744 | 0.64 | ALDH1A1 (0.33) | TSHR | |
| SCHEMBL8568629 | 0.64 | ALDH1A1 (0.33) | TSHR | |
| SCHEMBL28802487 | 0.64 | ALDH1A1 (0.33) | TSHR | |
| SCHEMBL3535287 | 0.64 | ALDH1A1 (0.33) | TSHR | |
| SCHEMBL2405628 | 0.64 | ALDH1A1 (0.33) | TSHR | |
| SCHEMBL8573008 | 0.64 | ALDH1A1 (0.33) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213663-B1 | Preparation of halogenated N-heteroaromatic polyhalogen derivatives | SALTIGO GMBH (DE) | 2011-09-28 | — | — | EP | disclosed |
| EP-1345908-B1 | PROCESS FOR THE PREPARATION OF ALPHA-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES | MERCK PATENT GMBH (DE) | 2011-07-27 | — | — | EP | disclosed |
| EP-2256104-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | Merck Patent GmbH (DE) | 2010-12-01 | — | — | EP | disclosed |
| EP-2213663-A1 | Preparation of halogenated N-heteroaromatic polyhalogen derivatives | Saltigo GmbH (DE) | 2010-08-04 | — | — | EP | disclosed |
| US-7166720-B2 | Process for the preparation of α-aminosubstituted carboxylic acid amides | MERCK PATENT GESELLSCHAFT (DE) | 2007-01-23 | — | — | US | disclosed |
| US-7053211-B2 | Process for the preparation of α-aminosubstituted carboxylic acid amides | MERCK PATENT GMBH (DE) | 2006-05-30 | — | — | US | disclosed |
| US-20060025587-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | HARTIG THORSTEN | 2006-02-02 | — | — | US | disclosed |
| US-20040034250-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2004-02-19 | — | — | US | disclosed |
| EP-1345908-A2 | PROCESS FOR THE PREPARATION OF ALPHA-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES | MERCK PATENT GmbH (DE) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002051813-A2 | PROCESS FOR THE PREPARATION OF α-AMINOSUBSTITUTED CARBOXYLIC ACID AMIDES | MERCK PATENT GMBH (DE) | 2002-07-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034250-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | ASNS, HNMT, NAAA | TSHR 3019/4885 |
| US-20060025587-A1 | Process for the preparation of alpha-aminosubstituted carboxylic acid amides | ASNS, HNMT, AASDHPPT | TSHR 2831/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.