Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | L3MBTL4 | Q8NA19 | 1/20 | 0.43 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.43 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22175864 | 0.85 | MPO (0.42) | ALDH1A1MAPTHTTLMNASIGMAR1 | |
| SCHEMBL6616305 | 0.81 | CYP46A1 (0.44) | ALDH1A1L3MBTL1CYP46A1TDP1NR4A2 | |
| SCHEMBL22176120 | 0.80 | L3MBTL4 (0.62) | ALDH1A1L3MBTL1L3MBTL4L3MBTL3CYP46A1 | |
| SCHEMBL22175862 | 0.80 | L3MBTL4 (0.62) | ALDH1A1L3MBTL1L3MBTL4L3MBTL3CYP46A1 | |
| SCHEMBL22176523 | 0.78 | SIGMAR1 (0.37) | ALDH1A1L3MBTL1L3MBTL4L3MBTL3TDP1 | |
| SCHEMBL22175908 | 0.78 | SIGMAR1 (0.37) | ALDH1A1L3MBTL1L3MBTL4L3MBTL3TDP1 | |
| SCHEMBL22175863 | 0.78 | SIGMAR1 (0.37) | ALDH1A1L3MBTL1L3MBTL4L3MBTL3TDP1 | |
| SCHEMBL22176104 | 0.78 | L3MBTL4 (0.63) | ALDH1A1L3MBTL1L3MBTL4L3MBTL3CYP46A1 | |
| SCHEMBL13469243 | 0.77 | CYP46A1 (0.51) | ALDH1A1L3MBTL1CYP46A1TDP1NR4A2 | |
| SCHEMBL12878887 | 0.77 | NR4A2 (0.43) | ALDH1A1L3MBTL1CYP46A1TDP1NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |
| WO-2020138015-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | 大正製薬株式会社 | 2020-07-02 | — | — | WO | disclosed |