Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.47 |
| ▸ | ATP4B | P51164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | HPGDS | O60760 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9984662 | 0.92 | ATP4A (0.44) | ATP4AATP4BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL14320438 | 0.89 | RAB9A (0.48) | ATP4AATP4BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL1287152 | 0.83 | RAB9A (0.56) | ATP4AATP4BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL17183525 | 0.83 | ALDH1A1 (0.63) | ALDH1A1SMN1; SMN2L3MBTL1GAAHPGDS | |
| SCHEMBL14320286 | 0.81 | BAZ2A (0.46) | ATP4AATP4BALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL28730742 | 0.79 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1GAAHPGDS | |
| SCHEMBL21774235 | 0.79 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2L3MBTL1GAAHPGDS | |
| SCHEMBL27402230 | 0.79 | GAA (0.58) | GAAKDM4EVCP | |
| Cyanide SCHEMBL27913373 | 0.78 | L3MBTL1 (0.57) | ALDH1A1SMN1; SMN2L3MBTL1GAAHPGDS | |
| SCHEMBL21774252 | 0.76 | SMN1; SMN2 (0.54) | ALDH1A1SMN1; SMN2L3MBTL1GAAHPGDS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9174949-B2 | Hedgehog inhibitors | SELEXAGEN THERAPEUTICS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174949-B2 | Hedgehog inhibitors | SELEXAGEN THERAPEUTICS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-9174949-B2 | Hedgehog inhibitors | SELEXAGEN THERAPEUTICS, INC. (US) | 2015-11-03 | — | — | US | disclosed |
| US-20130012513-A1 | HEDGEHOG INHIBITORS | SELEXAGEN THERAPEUTICS, INC. | 2013-01-10 | — | — | US | disclosed |
| US-20130012513-A1 | HEDGEHOG INHIBITORS | SELEXAGEN THERAPEUTICS, INC. | 2013-01-10 | — | — | US | disclosed |
| US-20130012513-A1 | HEDGEHOG INHIBITORS | SELEXAGEN THERAPEUTICS, INC. | 2013-01-10 | — | — | US | disclosed |
| EP-2521451-A1 | HEDGEHOG INHIBITORS | Selexagen Therapeutics, Inc. (US) | 2012-11-14 | — | — | EP | disclosed |
| WO-2011085128-A1 | HEDGEHOG INHIBITORS | SELEXAGEN THERAPEUTICS, INC. (US) | 2011-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012513-A1 | HEDGEHOG INHIBITORS | SHH, SMO, GLI1 | ATP4A 4309/4885ATP4B 4063/4885ALDH1A1 2913/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.