SCHEMBL2218755

SCHEMBL2218755

CNC(=S)NN=CC(C)=NNC(=S)NC

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 5/20 0.42
GAA P10253 2/20 0.42
TDP1 Q9NUW8 1/20 0.42
LMNA P02545 3/20 0.40
POLB P06746 1/20 0.39
HTT P42858 1/20 0.39
ALDH1A1 P00352 4/20 0.38
ALOX12 P18054 3/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
GLA P06280 1/20 0.38
MAPK1 P28482 1/20 0.38
RAB9A P51151 1/20 0.38
TOP2A P11388 2/20 0.37
KMT2A Q03164 3/20 0.36
MEN1 O00255 2/20 0.36
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29388303 1.00 NPSR1 (0.42) NPSR1GAATDP1LMNAPOLB
SCHEMBL3760199 0.98 NPSR1 (0.41) NPSR1GAATDP1LMNAPOLB
SCHEMBL13856955 0.88 ALDH1A1 (0.40) NPSR1GAATDP1LMNAHTT
SCHEMBL21761606 0.87 LMNA (0.36) NPSR1GAATDP1LMNAPOLB
SCHEMBL21761734 0.87 NPSR1 (0.37) NPSR1GAATDP1LMNAPOLB
SCHEMBL21761605 0.82 LMNA (0.35) NPSR1GAATDP1LMNAPOLB
SCHEMBL21761736 0.82 MAPK1 (0.38) NPSR1GAATDP1LMNAALDH1A1
SCHEMBL13856952 0.79 ALDH1A1 (0.44) NPSR1GAATDP1LMNAHTT
SCHEMBL3760193 0.73 POLB (0.35) NPSR1GAATDP1LMNAPOLB
SCHEMBL15841319 0.73 POLB (0.35) NPSR1GAATDP1LMNAPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 60 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012075591-A1 IN VITRO MITOCHONDRIAL FUNCTION TEST (MFT) AND USES THEREOF ARSENAULT ANDRE (CA) 2012-06-14 WO claimed
US-20260137818-A1 HIGH PURITY COPPER RADIOPHARMACEUTICAL COMPOSITIONS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF NUCLIDIUM AG (CH) 2026-05-21 US disclosed
US-12622984-B2 High purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof NUCLIDIUM AG (CH) 2026-05-12 US disclosed
US-20260083865-A1 PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS AND USE THEREOF 3B PHARMACEUTICALS GMBH (DE) 2026-03-26 US disclosed
US-12527885-B2 High purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof NUCLIDIUM AG (CH) 2026-01-20 US disclosed
WO-2025260130-A1 COMPOUNDS AND USES THEREOF THE UNIVERSITY OF MELBOURNE (AU) 2025-12-26 WO disclosed
US-20250339569-A1 CARBONIC ANHYDRASE IX LIGANDS 3B PHARMACEUTICALS GMBH (DE) 2025-11-06 US disclosed
US-20250296971-A1 GASTRIC INHIBITORY PEPTIDE RECEPTOR LIGANDS 3B PHARMACEUTICALS GMBH (DE) 2025-09-25 US disclosed
EP-4610269-A1 UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR (UPAR) LIGANDS FOR DIAGNOSTIC OR THERAPEUTIC USE 3B Pharmaceuticals GmbH (DE) 2025-09-03 EP disclosed
EP-4591330-A2 SOLID TARGET SYSTEMS FOR THE PRODUCTION OF HIGH-PURITY RADIONUCLIDE COMPOSITIONS Nuclidium AG (CH) 2025-07-30 EP disclosed
US-20110177004-A1 Version of FDG Detectable by Single-Photon Emission Computed Tomography OCERA THERAPEUTICS LLC (F/K/A OCERA THERAPEUTICS, INC.) 2011-07-21 US disclosed
EP-1670520-A4 MINIATURIZED 62ZN/62CU GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62CU KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED CU-BIS(THIOSEMICARBAZONE) COMPOUNDS PROPORTIONAL TECHNOLOGIES INC (US) 2009-07-22 EP disclosed
US-20060275208-A1 Miniaturized 62zn/62cu generator for high concentration clinical delivery of 62cu kit formulation for the facile preparation of radiolabeled cu-bis(thiosemicarbazone)compounds LACY JEFFREY L 2006-12-07 US disclosed
EP-1670520-A2 MINIATURIZED 62ZN/62CU GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62CU KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED CU-BIS(THIOSEMICARBAZONE) COMPOUNDS Proportional Technologies, Inc. (US) 2006-06-21 EP disclosed
US-20060018827-A1 Positron therapy of inflammation, infection and disease MONTEFIORE MEDICAL CENTER 2006-01-26 US disclosed
WO-2005084168-A2 MINIATURIZED 62Zn/62Cu GENERATOR FOR HIGH CONCENTRATION CLINICAL DELIVERY OF 62Cu KIT FORMULATION FOR THE FACILE PREPARATION OF RADIOLABELED Cu-BIS(THIOSEMICARBAZONE) COMPOUNDS PROPORTIONAL TECHNOLOGIES, INC. (US) 2005-09-15 WO disclosed
EP-0726077-B1 Radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative NIHON MEDIPHYSICS CO LTD (JP) 2001-12-12 EP disclosed
US-5843400-A Diagnostic agent for hypoxia or mitochondrial dysfunction comprising radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative NIHON MEDI-PHYSICS CO., LTD. (JP) 1998-12-01 US disclosed
EP-0726077-A2 Radioactive copper complex of dithiosemicarbazone derivative or diamine diol schiff base derivative NIHON MEDI-PHYSICS Co., Ltd. (JP) 1996-08-14 EP disclosed
US-5079346-A High uptake in heart, lipid soluble; myocardial perfusion imaging TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1992-01-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110177004-A1 Version of FDG Detectable by Single-Photon Emission Computed Tomography SLC2A1, SLC2A4, SLC2A3 NPSR1 4448/4885GAA 39/4885TDP1 3943/4885
US-20260083865-A1 PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) LIGANDS AND USE THEREOF KLK3, FOLH1, PSMA1 NPSR1 81/4885GAA 449/4885TDP1 3533/4885
US-20250296971-A1 GASTRIC INHIBITORY PEPTIDE RECEPTOR LIGANDS GIPR, VIP, GRPR NPSR1 27/4885GAA 2433/4885TDP1 4783/4885
US-12527885-B2 High purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof SSTR1, PSMA1, KLK3 NPSR1 107/4885GAA 266/4885TDP1 2926/4885
US-20260137818-A1 HIGH PURITY COPPER RADIOPHARMACEUTICAL COMPOSITIONS AND DIAGNOSTIC AND THERAPEUTIC USES THEREOF FAP, SSTR1, PSMA1 NPSR1 202/4885GAA 317/4885TDP1 1379/4885
US-20060275208-A1 Miniaturized 62zn/62cu generator for high concentration clinical delivery of 62cu kit formulation for the facile preparation of radiolabeled cu-bis(thiosemicarbazone)compounds KIT, SLC30A6, SOD1 NPSR1 2547/4885GAA 158/4885TDP1 3027/4885
US-20250339569-A1 CARBONIC ANHYDRASE IX LIGANDS CA9, CA13, CA4 NPSR1 642/4885GAA 128/4885TDP1 4334/4885
US-12622984-B2 High purity copper radiopharmaceutical compositions and diagnostic and therapeutic uses thereof SSTR2, SSTR1, SSTR3 NPSR1 61/4885GAA 2249/4885TDP1 3699/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.