Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.44 |
| ▸ | PLAU | P00749 | 2/20 | 0.44 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.42 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22188909 | 0.91 | PLA2G4A (0.52) | ELANEF2PLAUCTRB1KLKB1 | |
| SCHEMBL29263665 | 0.82 | NR4A2 (0.59) | ELANEF2PLAUCTRB1KLKB1 | |
| SCHEMBL22188916 | 0.82 | EPHX2 (0.50) | — | |
| SCHEMBL3679305 | 0.81 | PLA2G4A (0.61) | PLA2G4ALTB4R | |
| SCHEMBL9485938 | 0.81 | MAPK1 (0.60) | ELANEGAAMAPK1HTTNPSR1 | |
| SCHEMBL22188908 | 0.78 | ALDH1A1 (0.56) | HTTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9486190 | 0.77 | POLB (0.47) | GAAMAPK1HTTNPSR1MEN1 | |
| SCHEMBL22188914 | 0.76 | POLB (0.62) | ELANEF2PLAUCTRB1KLKB1 | |
| SCHEMBL13767657 | 0.75 | PLA2G4A (0.61) | ELANEF2PLAUCTRB1KLKB1 | |
| SCHEMBL28265756 | 0.74 | MAPT (0.46) | ELANEF2PLAUCTRB1KLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10752585-B2 | Process for the preparation of Zafirlukast and analogs thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-08-25 | — | — | US | disclosed |
| US-20200216390-A1 | PROCESS FOR THE PREPARATION OF ZAFIRLUKAST AND ANALOGS THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10752585-B2 | Process for the preparation of Zafirlukast and analogs thereof | CHUK, HRH2, CTSH | ELANE 3599/4885F2 1154/4885PLAU 961/4885 |
| US-20200216390-A1 | PROCESS FOR THE PREPARATION OF ZAFIRLUKAST AND ANALOGS THEREOF | CHUK, CTSH, HRH2 | ELANE 3704/4885F2 1138/4885PLAU 781/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.