Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22499169 | 0.83 | ALDH1A1 (0.40) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2921155 | 0.81 | ALDH1A1 (0.38) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL5253685 | 0.81 | ALDH1A1 (0.38) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL2745538 | 0.78 | KMT2A (0.36) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL11478718 | 0.73 | MMP13 (0.39) | ALDH1A1TSHRCYP3A4CA1CA2 | |
| SCHEMBL13789513 | 0.69 | CA1 (0.36) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7467674 | 0.66 | GAA (0.52) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL7467668 | 0.66 | GAA (0.52) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL4859251 | 0.66 | ALDH1A1 (0.61) | ALDH1A1F2PRSS1PRSS2PRSS3 | |
| SCHEMBL30835344 | 0.65 | ALDH1A1 (0.39) | ALDH1A1F2PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11370769-B2 | TRPC5 inhibitors and methods of using same | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2022-06-28 | — | — | US | disclosed |
| US-20200216411-A1 | TRPC5 INHIBITORS AND METHODS OF USING SAME | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200216411-A1 | TRPC5 INHIBITORS AND METHODS OF USING SAME | TRPC5, TRPC1, TRPC7 | ALDH1A1 4011/4885F2 4877/4885PRSS1 149/4885 |
| US-11370769-B2 | TRPC5 inhibitors and methods of using same | TRPC5, TRPC1, TRPC7 | ALDH1A1 4011/4885F2 4877/4885PRSS1 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.