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Fludrocortisone Acetate

Fludrocortisone Acetate

SCHEMBL22191189

CC(=O)OCC(=O)[C@@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C.C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2[C@@H](O)C[C@@]2(C)[C@H]1CC[C@]2(O)C(=O)CO

nearest known ligand 0.77

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C2

The experimentally established mechanism targets of Fludrocortisone Acetate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C2 known ✓ P08235 1/20 0.69
▸ HIF1A Q16665 13/20 0.77
▸ PGR P06401 5/20 0.77
▸ NR3C1 P04150 4/20 0.77
▸ HRH1 P35367 1/20 0.77
▸ SERPINA6 P08185 3/20 0.75
▸ LMNA P02545 3/20 0.75
▸ AR P10275 2/20 0.75
▸ CHRM1 P11229 2/20 0.75
▸ SMN1; SMN2 Q16637 3/20 0.69
▸ CYP3A4 P08684 3/20 0.69
▸ CYP2C19 P33261 2/20 0.69
▸ HSD17B10 Q99714 2/20 0.69
▸ NFKB1 P19838 2/20 0.69
▸ MAPT P10636 2/20 0.69
▸ SHBG P04278 1/20 0.69
▸ KMT2A Q03164 1/20 0.69
▸ PMP22 Q01453 1/20 0.61
▸ TSHR P16473 1/20 0.61
▸ FNTA P49354 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fludrocortisone SCHEMBL1333577 0.94 NR3C1 (0.80) HIF1APGRNR3C1HRH1SERPINA6
Fludrocortisone Acetate SCHEMBL20494161 0.91 NR3C1 (0.93) HIF1APGRNR3C1HRH1SERPINA6
Fludrocortisone Acetate SCHEMBL5967523 0.90 HIF1A (0.72) HIF1APGRNR3C1HRH1SERPINA6
Hydrocortisone Acetate SCHEMBL365254 0.90 HIF1A (0.93) HIF1APGRNR3C1SERPINA6LMNA
Hydrocortisone Acetate SCHEMBL7520412 0.90 HIF1A (0.93) HIF1APGRNR3C1SERPINA6LMNA
Fludrocortisone Acetate SCHEMBL5309905 0.89 HIF1A (0.68) HIF1APGRNR3C1HRH1SERPINA6
Fludrocortisone Acetate SCHEMBL539744 0.88 NR3C1 (1.00) HIF1APGRNR3C1HRH1SERPINA6
Fludrocortisone Acetate SCHEMBL10871295 0.88 NR3C1 (1.00) HIF1APGRNR3C1HRH1SERPINA6
Fludrocortisone Acetate SCHEMBL4737 0.88 NR3C1 (1.00) HIF1APGRNR3C1HRH1SERPINA6
Hydrocortisone Acetate SCHEMBL7419 0.87 HIF1A (1.00) HIF1APGRNR3C1SERPINA6LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3905880-B1 SUPPLEMENTED SERUM-CONTAINING CULTURE MEDIUM FOR ENHANCED ARPE-19 GROWTH AND HUMAN CYTOMEGALOVIRUS VACCINE PRODUCTION MERCK SHARP & DOHME LLC (US) 2024-06-12 — — EP disclosed
EP-3905880-A1 SUPPLEMENTED SERUM-CONTAINING CULTURE MEDIUM FOR ENHANCED ARPE-19 GROWTH AND HUMAN CYTOMEGALOVIRUS VACCINE PRODUCTION Merck Sharp & Dohme Corp. (US) 2021-11-10 — — EP disclosed
WO-2020142304-A1 SUPPLEMENTED SERUM-CONTAINING CULTURE MEDIUM FOR ENHANCED ARPE-19 GROWTH AND HUMAN CYTOMEGALOVIRUS VACCINE PRODUCTION MERCK SHARP & DOHME CORP. (US) 2020-07-09 — — WO disclosed
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