SCHEMBL2219631

SCHEMBL2219631

CC(C)Oc1nc(N)nc2c1ncn2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O

nearest known ligand 0.71

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 8/20 0.71
ADORA2B P29275 7/20 0.71
CYP2C19 P33261 1/20 0.67
SLC29A1 Q99808 5/20 0.66
ADORA3 P0DMS8 2/20 0.66
ADORA1 P30542 2/20 0.66
PGK1 P00558 1/20 0.61
PGK2 P07205 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6885317 0.89 ADORA2A (0.72) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL18820 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL2143756 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL9937290 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL14031852 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL18321891 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL13575801 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL13657986 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL20769831 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3
Nelarabine SCHEMBL1818971 0.88 CYP2C19 (0.71) ADORA2AADORA2BCYP2C19SLC29A1ADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12357664-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS (US) 2025-07-15 US claimed
EP-4023233-A2 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2022-07-06 EP claimed
EP-3518947-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2019-08-07 EP claimed
WO-2018064134-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2018-04-05 WO claimed
US-20180085411-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF SATOR THERAPEUTICS 2018-03-29 US claimed
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA UNIVERSITY OF WASHINGTON (US) 2005-08-25 US claimed
US-12521424-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS (US) 2026-01-13 US disclosed
EP-4023233-B1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2026-01-07 EP disclosed
EP-3518947-B1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2023-07-05 EP disclosed
EP-4023233-A2 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2022-07-06 EP disclosed
EP-4019029-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF Sator Therapeutics LLC (US) 2022-06-29 EP disclosed
US-20220088098-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF SATOR THERAPEUTICS 2022-03-24 US disclosed
US-11253558-B2 Optimized oncolytic viruses and uses thereof SATOR THERAPEUTICS 2022-02-22 US disclosed
US-20180085411-A1 OPTIMIZED ONCOLYTIC VIRUSES AND USES THEREOF SATOR THERAPEUTICS 2018-03-29 US disclosed
US-9771574-B2 Apparatus for continuous directed evolution of proteins and nucleic acids PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2017-09-26 US disclosed
EP-3199630-A1 CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS President and Fellows of Harvard College (US) 2017-08-02 EP disclosed
EP-2342336-B1 CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS HARVARD COLLEGE (US) 2016-12-14 EP disclosed
US-20150275202-A1 CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-10-01 US disclosed
US-9023594-B2 Continuous directed evolution of proteins and nucleic acids PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2015-05-05 US disclosed
US-20110177495-A1 CONTINUOUS DIRECTED EVOLUTION OF PROTEINS AND NUCLEIC ACIDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2011-07-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050187180-A1 Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA SAMHD1, BCDIN3D, DCTD ADORA2A 2027/4885ADORA2B 2136/4885CYP2C19 3339/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.