Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP2 | P42575 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.39 |
| ▸ | CA12 | O43570 | 2/20 | 0.39 |
| ▸ | F13A1 | P00488 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | CA6 | P23280 | 2/20 | 0.39 |
| ▸ | CA5A | P35218 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10737266 | 0.93 | HRH3 (0.47) | MAPTRAB9AHRH3KDM4EALDH1A1 | |
| SCHEMBL13103613 | 0.86 | RAB9A (0.47) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL6645913 | 0.86 | MAPT (0.53) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL12830407 | 0.79 | MAPT (0.47) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL20613270 | 0.78 | RAB9A (0.50) | MAPTRAB9AKDM4EALDH1A1GAA | |
| Norspermidine SCHEMBL713427 | 0.78 | CYP1A2 (0.57) | CASP2MAPTCA12F13A1CA2 | |
| SCHEMBL10604098 | 0.77 | HCAR3 (0.59) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL10293613 | 0.77 | HCAR3 (0.57) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL10483888 | 0.77 | IL6 (0.41) | NOS3NOS2 | |
| Bromide SCHEMBL10609035 | 0.76 | HCAR3 (0.58) | MAPTRAB9AKDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142228-A1 | ANDROGEN RECEPTOR PROTEIN DEGRADERS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2020-07-09 | — | — | WO | disclosed |