Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.46 |
| ▸ | CCR5 | P51681 | 1/20 | 0.46 |
| ▸ | CCR8 | P51685 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | NOS3 | P29474 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12830407 | 0.92 | MAPT (0.47) | MAPTRAB9AKDM4ECCR1CCR5 | |
| SCHEMBL10293613 | 0.90 | HCAR3 (0.57) | MAPTRAB9AKDM4ECCR1CCR5 | |
| SCHEMBL10737266 | 0.89 | HRH3 (0.47) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL12832042 | 0.88 | RAB9A (0.52) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL13103613 | 0.88 | RAB9A (0.47) | MAPTRAB9AKDM4ECCR1CCR5 | |
| SCHEMBL12832443 | 0.87 | CYP2C19 (0.56) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL10604098 | 0.86 | HCAR3 (0.59) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL22197869 | 0.86 | CASP2 (0.43) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL12060 | 0.85 | CYP2C19 (0.57) | MAPTRAB9AKDM4EALDH1A1GAA | |
| SCHEMBL11563180 | 0.85 | ALDH1A1 (0.51) | MAPTRAB9AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1087963-B1 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORP (US) | 2004-08-25 | — | — | EP | disclosed |