N-Methyl-D-Aspartic Acid (Nmda)

N-Methyl-D-Aspartic Acid (Nmda)

SCHEMBL2220

CN[C@H](CC(=O)O)C(=O)O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.45
CA4 P22748 1/20 0.45
TDP1 Q9NUW8 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.42
MME P08473 4/20 0.40
GNPAT O15228 1/20 0.40
SLC22A6 Q4U2R8 1/20 0.39
FOLH1 Q04609 1/20 0.38
RIMKLA Q8IXN7 1/20 0.38
NAALAD2 Q9Y3Q0 1/20 0.38
KDM4E B2RXH2 1/20 0.38
MAPT P10636 1/20 0.38
THRB P10828 1/20 0.38
ALOX15 P16050 1/20 0.38
NFKB1 P19838 1/20 0.38
PTGS2 P35354 1/20 0.38
THPO P40225 1/20 0.38
RECQL P46063 1/20 0.38
BLM P54132 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL18528187 1.00 CA2 (0.45) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL19741548 1.00 CA2 (0.45) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL167682 1.00 CA2 (0.45) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL163692 1.00 CA2 (0.45) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL11297426 0.97 CA2 (0.44) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL6954583 0.97 CA2 (0.44) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL27949540 0.97 CA2 (0.44) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL10763594 0.97 CA2 (0.44) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL28052876 0.95 CA2 (0.42) CA2CA4TDP1SMN1; SMN2MME
N-Methyl-D-Aspartic Acid (Nmda) SCHEMBL431199 0.91 GLRA1 (0.43) CA2CA4TDP1SMN1; SMN2MME

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 38858 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-121902886-B Digital impulse neuron, impulse neural network and realization method thereof 中国科学技术大学 2026-05-22 CN claimed
US-20260139860-A1 PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS CENTRE FOR DIGESTIVE DISEASES (AU) 2026-05-21 US claimed
WO-2026102000-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS RELATED TO GLUCOSYLCERAMIDASE BETA 1 DEFICIENCY VOYAGER THERAPEUTICS, INC. (US) 2026-05-15 WO claimed
US-20260130871-A1 COMPOUNDS AND COMBINATIONS THEREOF FOR TREATING NEUROLOGICAL AND PSYCHIATRIC CONDITIONS ANTECIP BIOVENTURES II LLC (US) 2026-05-14 US claimed
US-12622932-B2 Immunomodulatory cells and uses thereof SINAI HEALTH SYSTEM (CA) 2026-05-12 US claimed
CN-122029177-A Oligonucleotides containing multiple ligands and/or lipids 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122029176-A Containing a plurality of oligonucleotides modified oligonucleotides 阿达尔克斯制药有限公司 2026-05-12 CN claimed
CN-122028913-A Oligonucleotides containing ligands in nucleobases, 2 'or 3' positions 阿达尔克斯制药有限公司 2026-05-12 CN claimed
US-12616807-B2 Medical counter measures including dry powder formulations and associated methods Belhaven BioPharma Inc. (US) 2026-05-05 US claimed
US-20260118363-A1 Application of GLUN2A and NMDA Receptor Containing GLUN2A as Targets in Screening Drugs for Treating Depression SYNPHATEC SHANGHAI BIOPHARMACEUTICAL TECH CO LTD (CN) 2026-04-30 US claimed
US-4888347-A Use of specific N-methyl-D-aspartate receptor antagonists in the prevention and treatment of neurodegeneration MERCK SHARP & DOHME LIMITED (GB) 1989-12-19 US claimed
US-4870079-A ANTICONVULSANTS, ANTAGONISTS OF N-METHYL-D-ASPARTATE MERCK & CO., INC. (US) 1989-09-26 US claimed
WO-1989007098-A1 BUTYRL-TYROSINYL SPERMINE, ANALOGS THEREOF AND METHODS OF PREPARING AND USING SAME THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF (US) 1989-08-10 WO claimed
EP-0324595-A2 Amino-functional compounds as builders/dispersants in detergent compositions THE PROCTER & GAMBLE COMPANY (US) 1989-07-19 EP claimed
WO-1989005641-A1 DEXTROMETHORPHAN POTENTIATOR FOR ANTICONVULSANT COMPOSITION AND METHOD PONTECORVO MICHAEL J (US) 1989-06-29 WO claimed
EP-0303387-A1 Kynurenic acid derivatives useful in the treatment of neurodegenerative disorders MERCK SHARP & DOHME LTD. (GB) 1989-02-15 EP claimed
WO-1988007851-A1 LIPOSOME ENTRAPPED N-METHYL-D-ASPARTATE RECEPTOR BLOCKERS INNOVATIVE THERAPEUTICS CORPORATION (US) 1988-10-20 WO claimed
WO-1988007811-A2 TREATMENT OF TRAUMATIC INJURY WITH NMDA RECEPTOR BLOCKERS INNOVATIVE THERAPEUTICS CORPORATION (US) 1988-10-20 WO claimed
US-4746653-A ANTAGONISTS OF N-METHYL-D-ASPARTATE SENSITIVE EXCITATORY AMINO ACID RECEPTOR; TREATMENT OF MUSCULAR SPASMS, CONVULSIVE DISORDERS AND ANXIETY CIBA-GEIGY CORPORATION (US) 1988-05-24 US claimed
EP-0203891-A2 Certain phosphonic acids and derivatives CIBA-GEIGY AG (CH) 1986-12-03 EP claimed