Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOX | P28300 | 1/20 | 0.35 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.35 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RGS12 | O14924 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744607 | 0.57 | GSK3A (0.31) | — | |
| SCHEMBL15250844 | 0.55 | SMN1; SMN2 (0.40) | ALDH1A1CYP1A2CYP3A4MAPTKDM4E | |
| SCHEMBL8349801 | 0.55 | CYP1A2 (0.42) | LOXLOXL3LOXL4LOXL2CYP1A2 | |
| SCHEMBL18911790 | 0.53 | SIGMAR1 (0.37) | LOXLOXL3LOXL4LOXL2ALDH1A1 | |
| SCHEMBL18911716 | 0.53 | ALDH1A1 (0.35) | LOXLOXL3LOXL4LOXL2ALDH1A1 | |
| SCHEMBL20621571 | 0.53 | KDM4E (0.33) | ALDH1A1CYP1A2ALOX15HSD17B10CYP3A4 | |
| SCHEMBL416916 | 0.53 | KDM4E (0.61) | ALDH1A1CYP1A2HSD17B10MAPTKDM4E | |
| SCHEMBL3421771 | 0.53 | AVPR1A (0.67) | ALDH1A1ALOX15HSD17B10KDM4EHPGD | |
| SCHEMBL21373978 | 0.52 | MAPK1 (0.55) | ALDH1A1CYP1A2ALOX15HSD17B10MEN1 | |
| SCHEMBL6403525 | 0.52 | BPTF (0.54) | ALOX15HSD17B10CYP3A4MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200216449-A1 | 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof | Tang, YaJie (CN) | 2020-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200216449-A1 | 4-Sulfur Substituted Podophyllotoxin Derivative and Preparation Method Therefor and Use Thereof | TPMT, WEE1, DHFR | LOX 1849/4885LOXL3 2727/4885LOXL4 348/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.