Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 12/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 7/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | NAE1 | Q13564 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201358 | 0.87 | TGFBR1 (0.53) | ABCG2ABCB1TGFBR1PRKD1FGFR2 | |
| SCHEMBL22201352 | 0.85 | LMNA (0.52) | ABCG2ABCB1TGFBR1PRKD1FGFR2 | |
| SCHEMBL22201353 | 0.84 | ABCG2 (0.54) | ABCG2ABCB1TGFBR1PRKD1FGFR2 | |
| SCHEMBL22201341 | 0.80 | PRKD1 (0.66) | ABCG2ABCB1TGFBR1PRKD1ABCC1 | |
| SCHEMBL22201350 | 0.79 | ABCG2 (0.58) | ABCG2ABCB1TGFBR1PRKD1FGFR2 | |
| SCHEMBL22201347 | 0.79 | ABCG2 (0.58) | ABCG2ABCB1AURKAAURKBTGFBR1 | |
| SCHEMBL22201397 | 0.79 | ABCG2 (0.55) | ABCG2PRKD1FGFR2FLT3 | |
| SCHEMBL22201356 | 0.76 | HPGD (0.55) | ABCG2ABCB1TGFBR1PRKD1FGFR2 | |
| SCHEMBL22201354 | 0.76 | HPGD (0.55) | ABCG2ABCB1TGFBR1PRKD1FGFR2 | |
| SCHEMBL22201395 | 0.76 | FGFR2 (0.55) | ABCG2ABCB1TGFBR1PRKD1FGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |