Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.51 |
| ▸ | GBA1 | P04062 | 2/20 | 0.50 |
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22201360 | 0.80 | PDE5A (0.77) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL1083761 | 0.73 | HPGD (1.00) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL22201524 | 0.72 | LMNA (0.58) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL22201623 | 0.72 | ABCG2 (0.86) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL4867531 | 0.71 | MEN1 (0.76) | LMNAALDH1A1POLBABCG2GBA1 | |
| SCHEMBL22201525 | 0.71 | LMNA (0.56) | LMNAHPGDALDH1A1POLBGSK3A | |
| SCHEMBL1501342 | 0.70 | CYP11B1 (0.69) | GSK3B | |
| SCHEMBL4856772 | 0.69 | GBA1 (0.82) | LMNAABCG2GBA1PDE5AKDM4E | |
| SCHEMBL3459669 | 0.68 | PDE5A (0.85) | LMNAHPGDALDH1A1POLBGBA1 | |
| SCHEMBL1064930 | 0.68 | TGFBR1 (0.78) | LMNAHPGDALDH1A1POLBGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |