Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | GSK3A | P49840 | 1/20 | 0.71 |
| ▸ | GSK3B | P49841 | 1/20 | 0.71 |
| ▸ | ABCG2 | Q9UNQ0 | 13/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.54 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14727474 | 0.84 | ABCG2 (0.69) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL14727478 | 0.84 | ABCG2 (0.59) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL1083761 | 0.83 | HPGD (1.00) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL22201289 | 0.80 | ABCG2 (0.79) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL1083806 | 0.77 | MEN1 (0.71) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL1064930 | 0.76 | TGFBR1 (0.78) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL22201628 | 0.75 | ABCG2 (0.83) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL22201264 | 0.74 | ABCG2 (0.71) | HPGDLMNAALDH1A1POLBGSK3A | |
| SCHEMBL668559 | 0.74 | EGFR (1.00) | ABCG2EGFRMAPK14 | |
| SCHEMBL12258624 | 0.74 | CSNK2A1 (0.73) | HPGDLMNAALDH1A1POLBGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020142748-A1 | METHODS AND MATERIALS FOR INCREASING TRANSCRIPTION FACTOR EB POLYPEPTIDE LEVELS | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2020-07-09 | — | — | WO | disclosed |